inclusion criteria: 1. signed informed consent from patient or legal representative; 2. age 18 or greater; 3. positive reverse transcription polymerase chain reaction (rt-pcr) for sars-cov-2 (≤10 days); 4. respiratory rate \> 20 rr; 5. spo2 \< 94% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ecmo; 6. chest x-ray confirming bilateral pulmonary infiltrates; 7. body mass index of ≤ 40 units/kg/m2; 8. adequate method of birth control.

inclusion criteria: 1. signed informed consent from patient or legal representative; 2. age 18 or greater; 3. positive reverse transcription polymerase chain reaction (rt-pcr) for sars-cov-2 (≤10 days); 4. respiratory rate \> 20 rr; 5. spo2 \< 94% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ecmo; 6. chest x-ray confirming bilateral pulmonary infiltrates; 7. body mass index of ≤ 40 units/kg/m2; 8. adequate method of birth control.

inclusion criteria: signed informed consent from patient or legal representative; age 18 or greater; positive reverse transcription polymerase chain reaction (rt-pcr) for sars-cov-2 (≤10 days); respiratory rate > 20 rr; spo2 < 94% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ecmo; chest x-ray confirming bilateral pulmonary infiltrates; body mass index of ≤ 40 units/kg/m2; adequate method of birth control.

inclusion criteria: signed informed consent from patient or legal representative; age 18 or greater; positive reverse transcription polymerase chain reaction (rt-pcr) for sars-cov-2 (≤10 days); respiratory rate > 20 rr; spo2 < 94% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ecmo; chest x-ray confirming bilateral pulmonary infiltrates; body mass index of ≤ 40 units/kg/m2; adequate method of birth control.

inclusion criteria: 1. signed informed consent from patient or legal representative; 2. age 18 or greater; 3. positive reverse transcription polymerase chain reaction (rt-pcr) for sars-cov-2 (≤10 days); 4. respiratory rate > 20 rr; 5. spo2 < 94% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ecmo; 6. chest x-ray confirming bilateral pulmonary infiltrates; 7. body mass index of ≤ 40 units/kg/m2; 8. adequate method of birth control.

inclusion criteria: 1. signed informed consent from patient or legal representative; 2. age 18 or greater; 3. positive reverse transcription polymerase chain reaction (rt-pcr) for sars-cov-2 (≤10 days); 4. respiratory rate > 20 rr; 5. spo2 < 94% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ecmo; 6. chest x-ray confirming bilateral pulmonary infiltrates; 7. body mass index of ≤ 40 units/kg/m2; 8. adequate method of birth control.

inclusion criteria: 1. signed informed consent from patient or legal representative; 2. age 18 or greater; 3. positive reverse transcription polymerase chain reaction (rt-pcr) for sars-cov-2 (<10 days); 4. respiratory rate > 20 rr; 5. spo2 < 92% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ecmo; 6. chest x-ray confirming bilateral pulmonary infiltrates; 7. body mass index of < 40 units/kg/m2; 8. adequate method of birth control.

inclusion criteria: 1. signed informed consent from patient or legal representative; 2. age 18 or greater; 3. positive reverse transcription polymerase chain reaction (rt-pcr) for sars-cov-2 (<10 days); 4. respiratory rate > 20 rr; 5. spo2 < 92% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ecmo; 6. chest x-ray confirming bilateral pulmonary infiltrates; 7. body mass index of < 40 units/kg/m2; 8. adequate method of birth control.