* fev 1 \<50%, fef 25-75 \<50% detected oxygen saturation \<85% at rest, * moderately severe heart failure, * has a disease that restricts its mobilization, * psychiatric illness, * advanced stage liver, advanced stage renal failure, * myocardial infarction within 4 months * having a history of unstable angina * active infectious disease

* fev 1 \<50%, fef 25-75 \<50% detected oxygen saturation \<85% at rest, * moderately severe heart failure, * has a disease that restricts its mobilization, * psychiatric illness, * advanced stage liver, advanced stage renal failure, * myocardial infarction within 4 months * having a history of unstable angina * active infectious disease

- fev 1 <50%, fef 25-75 <50% detected oxygen saturation <85% at rest, - moderately severe heart failure, - has a disease that restricts its mobilization, - psychiatric illness, - advanced stage liver, advanced stage renal failure, - myocardial infarction within 4 months - having a history of unstable angina - active infectious disease

- fev 1 <50%, fef 25-75 <50% detected oxygen saturation <85% at rest, - moderately severe heart failure, - has a disease that restricts its mobilization, - psychiatric illness, - advanced stage liver, advanced stage renal failure, - myocardial infarction within 4 months - having a history of unstable angina - active infectious disease