* pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use adequate contraception, which includes: 1. intrauterine devices (iud), contraceptive implants, or tubal sterilization 2. hormone method with a barrier method 3. two barrier methods 4. if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction * history of severe hematologic or neuromuscular disorder * co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein transport inhibitor * severe renal impairment with concomitant hepatic impairment * concurrent use of colchicine and strong or p-glycoprotein inhibitor with renal or hepatic impairment

* pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use adequate contraception, which includes: 1. intrauterine devices (iud), contraceptive implants, or tubal sterilization 2. hormone method with a barrier method 3. two barrier methods 4. if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction * history of severe hematologic or neuromuscular disorder * co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein transport inhibitor * severe renal impairment with concomitant hepatic impairment * concurrent use of colchicine and strong or p-glycoprotein inhibitor with renal or hepatic impairment

pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use adequate contraception, which includes: intrauterine devices (iud), contraceptive implants, or tubal sterilization hormone method with a barrier method two barrier methods if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction history of severe hematologic or neuromuscular disorder co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein transport inhibitor severe renal impairment with concomitant hepatic impairment concurrent use of colchicine and strong or p-glycoprotein inhibitor with renal or hepatic impairment

pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use adequate contraception, which includes: intrauterine devices (iud), contraceptive implants, or tubal sterilization hormone method with a barrier method two barrier methods if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction history of severe hematologic or neuromuscular disorder co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein transport inhibitor severe renal impairment with concomitant hepatic impairment concurrent use of colchicine and strong or p-glycoprotein inhibitor with renal or hepatic impairment

- pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use adequate contraception, which includes: 1. intrauterine devices (iud), contraceptive implants, or tubal sterilization 2. hormone method with a barrier method 3. two barrier methods 4. if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction - history of severe hematologic or neuromuscular disorder - co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein transport inhibitor - severe renal impairment with concomitant hepatic impairment - concurrent use of colchicine and strong or p-glycoprotein inhibitor with renal or hepatic impairment

- pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use adequate contraception, which includes: 1. intrauterine devices (iud), contraceptive implants, or tubal sterilization 2. hormone method with a barrier method 3. two barrier methods 4. if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction - history of severe hematologic or neuromuscular disorder - co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein transport inhibitor - severe renal impairment with concomitant hepatic impairment - concurrent use of colchicine and strong or p-glycoprotein inhibitor with renal or hepatic impairment

- pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use adequate contraception, which includes: 1. intrauterine devices (iud), contraceptive implants, or tubal sterilization 2. hormone method with a barrier method 3. two barrier methods 4. if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction - history of severe hematologic or neuromuscular disorder - co-administration of cypa3a4 and p-glycoprotein transport inhibitor - severe renal impairment with concomitant hepatic impairment - concurrent use of colchicine and strong or p-glycoprotein inhibitor with renal or hepatic impairment

- pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use adequate contraception, which includes: 1. intrauterine devices (iud), contraceptive implants, or tubal sterilization 2. hormone method with a barrier method 3. two barrier methods 4. if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction - history of severe hematologic or neuromuscular disorder - co-administration of cypa3a4 and p-glycoprotein transport inhibitor - severe renal impairment with concomitant hepatic impairment - concurrent use of colchicine and strong or p-glycoprotein inhibitor with renal or hepatic impairment