inclusion criteria: * age 18 years or above * written informed consent from the trial subject has been obtained * willing to follow contraception guidelines * tested positive for sars-cov-2 by pcr \<72 hours after swab * a maximum of 14 days between onset of symptoms and enrollment * who score 5 or * who score 4 with at least one additional risk factor for disease progression * acceptable risk factors are: * radiographically proven lung infiltrates * immunosuppression either by malignant disease or it's treatment, or other underlying diseases leading to immunodeficiency or underlying diseases that require treatment resulting in immunosuppression * immunosuppressive drugs or steroids at a prednisolone equivalent of \<1 mg/kg bw) * receipt of an autologous transplant within the last 5 years * receipt of an allogeneic transplant within the last 5 years or ongoing immunosuppression

inclusion criteria: * age 18 years or above * written informed consent from the trial subject has been obtained * willing to follow contraception guidelines * tested positive for sars-cov-2 by pcr \<72 hours after swab * a maximum of 14 days between onset of symptoms and enrollment * who score 5 or * who score 4 with at least one additional risk factor for disease progression * acceptable risk factors are: * radiographically proven lung infiltrates * immunosuppression either by malignant disease or it's treatment, or other underlying diseases leading to immunodeficiency or underlying diseases that require treatment resulting in immunosuppression * immunosuppressive drugs or steroids at a prednisolone equivalent of \<1 mg/kg bw) * receipt of an autologous transplant within the last 5 years * receipt of an allogeneic transplant within the last 5 years or ongoing immunosuppression

inclusion criteria: age 18 years or above written informed consent from the trial subject has been obtained willing to follow contraception guidelines tested positive for sars-cov-2 by pcr <72 hours after swab a maximum of 14 days between onset of symptoms and enrollment who score 5 or who score 4 with at least one additional risk factor for disease progression acceptable risk factors are: radiographically proven lung infiltrates immunosuppression either by malignant disease or it's treatment, or other underlying diseases leading to immunodeficiency or underlying diseases that require treatment resulting in immunosuppression immunosuppressive drugs or steroids at a prednisolone equivalent of <1 mg/kg bw) receipt of an autologous transplant within the last 5 years receipt of an allogeneic transplant within the last 5 years or ongoing immunosuppression

inclusion criteria: age 18 years or above written informed consent from the trial subject has been obtained willing to follow contraception guidelines tested positive for sars-cov-2 by pcr <72 hours after swab a maximum of 14 days between onset of symptoms and enrollment who score 5 or who score 4 with at least one additional risk factor for disease progression acceptable risk factors are: radiographically proven lung infiltrates immunosuppression either by malignant disease or it's treatment, or other underlying diseases leading to immunodeficiency or underlying diseases that require treatment resulting in immunosuppression immunosuppressive drugs or steroids at a prednisolone equivalent of <1 mg/kg bw) receipt of an autologous transplant within the last 5 years receipt of an allogeneic transplant within the last 5 years or ongoing immunosuppression

inclusion criteria: - age 18 years or above - written informed consent from the trial subject has been obtained - willing to follow contraception guidelines - tested positive for sars-cov-2 by pcr <72 hours after swab - who score 5 or - who score 4 with at least one additional risk factor for disease progression - acceptable risk factors are: - radiographically proven lung infiltrates - immunosuppression either by malignant disease or it's treatment, or other underlying diseases leading to immunodeficiency or underlying diseases that require treatment resulting in immunosuppression - immunosuppressive drugs for example 6mg dexamethasone per os or intravenous 1x/d (soc) and steroids at a prednisolone equivalent of <1 mg/kg bw) are allowed - autologous transplant during the past 3 months - allogeneic transplant during the past year or ongoing immunosuppression or chronic graft-versus-host disease

inclusion criteria: - age 18 years or above - written informed consent from the trial subject has been obtained - willing to follow contraception guidelines - tested positive for sars-cov-2 by pcr <72 hours after swab - who score 5 or - who score 4 with at least one additional risk factor for disease progression - acceptable risk factors are: - radiographically proven lung infiltrates - immunosuppression either by malignant disease or it's treatment, or other underlying diseases leading to immunodeficiency or underlying diseases that require treatment resulting in immunosuppression - immunosuppressive drugs for example 6mg dexamethasone per os or intravenous 1x/d (soc) and steroids at a prednisolone equivalent of <1 mg/kg bw) are allowed - autologous transplant during the past 3 months - allogeneic transplant during the past year or ongoing immunosuppression or chronic graft-versus-host disease