a. inclusion criteria: 1. clinical diagnosis of moderate to severe acute respiratory syndrome due to sars-cov2 defined as: 1.1. tachypnea: \> 24 breaths per minute 1.2. hypoxemia: arterial oxygen saturation \<94% in room air by pulse oximetry 1.3. presumptive (or confirmed) diagnosis of sars-cov2 infection by at least one of the following criteria: 1. polymerase chain reaction assay (+) for sars-cov2 2. serology (+) for sars-cov2 3. sars-cov2 antigen diagnostic tests (+) 4. chest ct with findings suggestive of the diagnosis of covid-19 in the presence of medical history or clinical signs compatible with the diagnosis of covid-19 2. signature of the informed consent form b.

a. inclusion criteria: 1. clinical diagnosis of moderate to severe acute respiratory syndrome due to sars-cov2 defined as: 1.1. tachypnea: \> 24 breaths per minute 1.2. hypoxemia: arterial oxygen saturation \<94% in room air by pulse oximetry 1.3. presumptive (or confirmed) diagnosis of sars-cov2 infection by at least one of the following criteria: 1. polymerase chain reaction assay (+) for sars-cov2 2. serology (+) for sars-cov2 3. sars-cov2 antigen diagnostic tests (+) 4. chest ct with findings suggestive of the diagnosis of covid-19 in the presence of medical history or clinical signs compatible with the diagnosis of covid-19 2. signature of the informed consent form b.

a. inclusion criteria: clinical diagnosis of moderate to severe acute respiratory syndrome due to sars-cov2 defined as: 1.1. tachypnea: > 24 breaths per minute 1.2. hypoxemia: arterial oxygen saturation <94% in room air by pulse oximetry 1.3. presumptive (or confirmed) diagnosis of sars-cov2 infection by at least one of the following criteria: polymerase chain reaction assay (+) for sars-cov2 serology (+) for sars-cov2 sars-cov2 antigen diagnostic tests (+) chest ct with findings suggestive of the diagnosis of covid-19 in the presence of medical history or clinical signs compatible with the diagnosis of covid-19 signature of the informed consent form b.

a. inclusion criteria: clinical diagnosis of moderate to severe acute respiratory syndrome due to sars-cov2 defined as: 1.1. tachypnea: > 24 breaths per minute 1.2. hypoxemia: arterial oxygen saturation <94% in room air by pulse oximetry 1.3. presumptive (or confirmed) diagnosis of sars-cov2 infection by at least one of the following criteria: polymerase chain reaction assay (+) for sars-cov2 serology (+) for sars-cov2 sars-cov2 antigen diagnostic tests (+) chest ct with findings suggestive of the diagnosis of covid-19 in the presence of medical history or clinical signs compatible with the diagnosis of covid-19 signature of the informed consent form b.

a. inclusion criteria: 1. clinical diagnosis of moderate to severe acute respiratory syndrome due to sars-cov2 defined as: 1.1. tachypnea: > 24 breaths per minute 1.2. hypoxemia: arterial oxygen saturation <94% in room air by pulse oximetry 1.3. presumptive (or confirmed) diagnosis of sars-cov2 infection by at least one of the following criteria: 1. polymerase chain reaction assay (+) for sars-cov2 2. serology (+) for sars-cov2 3. sars-cov2 antigen diagnostic tests (+) 4. chest ct with findings suggestive of the diagnosis of covid-19 in the presence of medical history or clinical signs compatible with the diagnosis of covid-19 2. signature of the informed consent form b.

a. inclusion criteria: 1. clinical diagnosis of moderate to severe acute respiratory syndrome due to sars-cov2 defined as: 1.1. tachypnea: > 24 breaths per minute 1.2. hypoxemia: arterial oxygen saturation <94% in room air by pulse oximetry 1.3. presumptive (or confirmed) diagnosis of sars-cov2 infection by at least one of the following criteria: 1. polymerase chain reaction assay (+) for sars-cov2 2. serology (+) for sars-cov2 3. sars-cov2 antigen diagnostic tests (+) 4. chest ct with findings suggestive of the diagnosis of covid-19 in the presence of medical history or clinical signs compatible with the diagnosis of covid-19 2. signature of the informed consent form b.

a. inclusion criteria: 1. clinical diagnosis of moderate to severe acute respiratory syndrome due to sars-cov2 defined as: 1.1. tachypnea: > 24 breaths per minute 1.2. hypoxemia: arterial oxygen saturation <94% in room air by pulse oximetry 1.3. presumptive (or confirmed) diagnosis of sars-cov2 infection by at least one of the following criteria: 1. pcr (+) for sars-cov2 2. serology (+) for sars-cov2 3. sars-cov2 antigen diagnostic tests (+) 4. chest ct with findings suggestive of the diagnosis of covid-19 in the presence of medical history or clinical signs compatible with the diagnosis of covid-19 2. signature of the informed consent form b.

a. inclusion criteria: 1. clinical diagnosis of moderate to severe acute respiratory syndrome due to sars-cov2 defined as: 1.1. tachypnea: > 24 breaths per minute 1.2. hypoxemia: arterial oxygen saturation <94% in room air by pulse oximetry 1.3. presumptive (or confirmed) diagnosis of sars-cov2 infection by at least one of the following criteria: 1. pcr (+) for sars-cov2 2. serology (+) for sars-cov2 3. sars-cov2 antigen diagnostic tests (+) 4. chest ct with findings suggestive of the diagnosis of covid-19 in the presence of medical history or clinical signs compatible with the diagnosis of covid-19 2. signature of the informed consent form b.