1. chronic renal dysfunction stage 4 (gfr \<30ml / min / 1.73m2 calculated by the chronic kidney disease epidemiology collaboration (ckd-epi) equation 2. patient on renal replacement therapy by dialysis 3. pregnant and lactating women 4. previous use of trimetazidine less than two weeks before hospital admission 5. any clinical condition at the investigator´s discretion likely to be associated with elevation of baseline hs-troponin \>99th percentile

1. chronic renal dysfunction stage 4 (gfr \<30ml / min / 1.73m2 calculated by the chronic kidney disease epidemiology collaboration (ckd-epi) equation 2. patient on renal replacement therapy by dialysis 3. pregnant and lactating women 4. previous use of trimetazidine less than two weeks before hospital admission 5. any clinical condition at the investigator´s discretion likely to be associated with elevation of baseline hs-troponin \>99th percentile

chronic renal dysfunction stage 4 (gfr <30ml / min / 1.73m2 calculated by the chronic kidney disease epidemiology collaboration (ckd-epi) equation patient on renal replacement therapy by dialysis pregnant and lactating women previous use of trimetazidine less than two weeks before hospital admission any clinical condition at the investigator´s discretion likely to be associated with elevation of baseline hs-troponin >99th percentile

chronic renal dysfunction stage 4 (gfr <30ml / min / 1.73m2 calculated by the chronic kidney disease epidemiology collaboration (ckd-epi) equation patient on renal replacement therapy by dialysis pregnant and lactating women previous use of trimetazidine less than two weeks before hospital admission any clinical condition at the investigator´s discretion likely to be associated with elevation of baseline hs-troponin >99th percentile

1. chronic renal dysfunction stage 4 (gfr <30ml / min / 1.73m2 calculated by the chronic kidney disease epidemiology collaboration (ckd-epi) equation 2. patient on renal replacement therapy by dialysis 3. pregnant and lactating women 4. previous use of trimetazidine less than two weeks before hospital admission 5. any clinical condition at the investigator´s discretion likely to be associated with elevation of baseline hs-troponin >99th percentile

1. chronic renal dysfunction stage 4 (gfr <30ml / min / 1.73m2 calculated by the chronic kidney disease epidemiology collaboration (ckd-epi) equation 2. patient on renal replacement therapy by dialysis 3. pregnant and lactating women 4. previous use of trimetazidine less than two weeks before hospital admission 5. any clinical condition at the investigator´s discretion likely to be associated with elevation of baseline hs-troponin >99th percentile

1. chronic renal dysfunction stage 4 (gfr <30ml / min / 1.73m2 calculated by the ckd-epi equation) 2. patient on renal replacement therapy by dialysis 3. pregnant and lactating women 4. previous use of trimetazidine less than two weeks before hospital admission 5. any clinical condition at the investigator´s discretion likely to be associated with elevation of baseline hs-troponin >99th percentile

1. chronic renal dysfunction stage 4 (gfr <30ml / min / 1.73m2 calculated by the ckd-epi equation) 2. patient on renal replacement therapy by dialysis 3. pregnant and lactating women 4. previous use of trimetazidine less than two weeks before hospital admission 5. any clinical condition at the investigator´s discretion likely to be associated with elevation of baseline hs-troponin >99th percentile