1. history of any other covid-19 investigational/or licensed vaccination. 2. unacceptable laboratory abnormality from screening (prior to first vaccination) or safety testing, as listed below \[abnormal complete blood count (cbc), random blood sugar level, renal function test (serum urea and creatinine), liver function tests, urine analysis report, positive serology for hepatitis c or hiv antibody or hepatitis b surface antigen\]. (subjects will be informed if their results are positive for hepatitis c, hiv 1 \& 2 antibody or hepatitis b surface antigen (hbsag) and will be referred to a primary care provider for follow up of these abnormal laboratory tests.) 3. confirmed sars-cov-2 at the time of screening using rt-pcr and elisa or clia method. 4. history of facial nerve paralysis 5. history of cold, sneezing, nasal obstruction in the past 3 days. 6. prescribed usage of any nasal spray/or nasal drop medication. 7. any significant abnormality altering the anatomy of the nose in a substantial way or nasopharynx that may interfere with the aims of the study and in particular any of the nasal assessments or viral challenge (historical nasal polyps can be included, but large nasal polyps causing current and significant symptoms and/or requiring regular treatments in the last month are excluded) 8. for women of child bearing potential, a positive serum pregnancy test (during screening within 45 days of enrolment) or positive urine pregnancy test (within 24 hours of administering each dose of vaccine). 9. temperature \>38.0°c (100.4°f) or symptoms of an acute self-limited illness such as an upper respiratory infection or gastroenteritis within three days prior to each dose of vaccine. 10. medical problems as a result of alcohol or illicit drug use during the past 12 months. 11. receipt of an experimental agent (vaccine, drug, device, etc.) within 60 days before enrolment or expects to receive an investigational agent during the study period. 12. receipt of any licensed vaccine within four weeks before enrolment in this study. 13. known sensitivity to any ingredient of the study vaccines, or a more severe allergic reaction and history of allergies in the past. 14. receipt of immunoglobulin or other blood products within the three months prior to vaccination in this study. 15. immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months. 16. long-term use (\> 2 weeks) of oral or parenteral steroids (glucocorticoids) or high-dose inhaled steroids (\>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding six months (nasal and topical steroids are allowed). 17. any history of hereditary angioedema or idiopathic angioedema. 18. any history of anaphylaxis in relation to vaccination. 19. any history of albumin-intolerance. 20. pregnancy, lactation, or willingness/intention to become pregnant during the study. 21. history of any cancer. 22. history of severe psychiatric conditions likely to affect participation in the study. 23. a bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder, or prior history of significant bleeding or bruising following im injections or venepuncture. 24. any other serious chronic illness requiring hospital specialist supervision. 25. chronic respiratory diseases like severe acute respiratory syndrome (sars), including mild asthma. 26. chronic cardiovascular disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness 27. morbidly obese (bmi≥35 kg/m2) or underweight (bmi ≤18 kg/m2). 28. living in the same household of any covid-19 positive person. 29. any other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol. re-vaccination exclusion criteri. 30. pregnancy. 31. anaphylactic reaction following administration of the investigational vaccine. 32. virologically confirmed cases of sars-cov-2 infection.

1. history of any other covid-19 investigational/or licensed vaccination. 2. unacceptable laboratory abnormality from screening (prior to first vaccination) or safety testing, as listed below \[abnormal complete blood count (cbc), random blood sugar level, renal function test (serum urea and creatinine), liver function tests, urine analysis report, positive serology for hepatitis c or hiv antibody or hepatitis b surface antigen\]. (subjects will be informed if their results are positive for hepatitis c, hiv 1 \& 2 antibody or hepatitis b surface antigen (hbsag) and will be referred to a primary care provider for follow up of these abnormal laboratory tests.) 3. confirmed sars-cov-2 at the time of screening using rt-pcr and elisa or clia method. 4. history of facial nerve paralysis 5. history of cold, sneezing, nasal obstruction in the past 3 days. 6. prescribed usage of any nasal spray/or nasal drop medication. 7. any significant abnormality altering the anatomy of the nose in a substantial way or nasopharynx that may interfere with the aims of the study and in particular any of the nasal assessments or viral challenge (historical nasal polyps can be included, but large nasal polyps causing current and significant symptoms and/or requiring regular treatments in the last month are excluded) 8. for women of child bearing potential, a positive serum pregnancy test (during screening within 45 days of enrolment) or positive urine pregnancy test (within 24 hours of administering each dose of vaccine). 9. temperature \>38.0°c (100.4°f) or symptoms of an acute self-limited illness such as an upper respiratory infection or gastroenteritis within three days prior to each dose of vaccine. 10. medical problems as a result of alcohol or illicit drug use during the past 12 months. 11. receipt of an experimental agent (vaccine, drug, device, etc.) within 60 days before enrolment or expects to receive an investigational agent during the study period. 12. receipt of any licensed vaccine within four weeks before enrolment in this study. 13. known sensitivity to any ingredient of the study vaccines, or a more severe allergic reaction and history of allergies in the past. 14. receipt of immunoglobulin or other blood products within the three months prior to vaccination in this study. 15. immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months. 16. long-term use (\> 2 weeks) of oral or parenteral steroids (glucocorticoids) or high-dose inhaled steroids (\>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding six months (nasal and topical steroids are allowed). 17. any history of hereditary angioedema or idiopathic angioedema. 18. any history of anaphylaxis in relation to vaccination. 19. any history of albumin-intolerance. 20. pregnancy, lactation, or willingness/intention to become pregnant during the study. 21. history of any cancer. 22. history of severe psychiatric conditions likely to affect participation in the study. 23. a bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder, or prior history of significant bleeding or bruising following im injections or venepuncture. 24. any other serious chronic illness requiring hospital specialist supervision. 25. chronic respiratory diseases like severe acute respiratory syndrome (sars), including mild asthma. 26. chronic cardiovascular disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness 27. morbidly obese (bmi≥35 kg/m2) or underweight (bmi ≤18 kg/m2). 28. living in the same household of any covid-19 positive person. 29. any other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol. re-vaccination exclusion criteri. 30. pregnancy. 31. anaphylactic reaction following administration of the investigational vaccine. 32. virologically confirmed cases of sars-cov-2 infection.

history of any other covid-19 investigational/or licensed vaccination. unacceptable laboratory abnormality from screening (prior to first vaccination) or safety testing, as listed below [abnormal complete blood count (cbc), random blood sugar level, renal function test (serum urea and creatinine), liver function tests, urine analysis report, positive serology for hepatitis c or hiv antibody or hepatitis b surface antigen]. (subjects will be informed if their results are positive for hepatitis c, hiv 1 & 2 antibody or hepatitis b surface antigen (hbsag) and will be referred to a primary care provider for follow up of these abnormal laboratory tests.) confirmed sars-cov-2 at the time of screening using rt-pcr and elisa or clia method. history of facial nerve paralysis history of cold, sneezing, nasal obstruction in the past 3 days. prescribed usage of any nasal spray/or nasal drop medication. any significant abnormality altering the anatomy of the nose in a substantial way or nasopharynx that may interfere with the aims of the study and in particular any of the nasal assessments or viral challenge (historical nasal polyps can be included, but large nasal polyps causing current and significant symptoms and/or requiring regular treatments in the last month are excluded) for women of child bearing potential, a positive serum pregnancy test (during screening within 45 days of enrolment) or positive urine pregnancy test (within 24 hours of administering each dose of vaccine). temperature >38.0°c (100.4°f) or symptoms of an acute self-limited illness such as an upper respiratory infection or gastroenteritis within three days prior to each dose of vaccine. medical problems as a result of alcohol or illicit drug use during the past 12 months. receipt of an experimental agent (vaccine, drug, device, etc.) within 60 days before enrolment or expects to receive an investigational agent during the study period. receipt of any licensed vaccine within four weeks before enrolment in this study. known sensitivity to any ingredient of the study vaccines, or a more severe allergic reaction and history of allergies in the past. receipt of immunoglobulin or other blood products within the three months prior to vaccination in this study. immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months. long-term use (> 2 weeks) of oral or parenteral steroids (glucocorticoids) or high-dose inhaled steroids (>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding six months (nasal and topical steroids are allowed). any history of hereditary angioedema or idiopathic angioedema. any history of anaphylaxis in relation to vaccination. any history of albumin-intolerance. pregnancy, lactation, or willingness/intention to become pregnant during the study. history of any cancer. history of severe psychiatric conditions likely to affect participation in the study. a bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder, or prior history of significant bleeding or bruising following im injections or venepuncture. any other serious chronic illness requiring hospital specialist supervision. chronic respiratory diseases like severe acute respiratory syndrome (sars), including mild asthma. chronic cardiovascular disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness morbidly obese (bmi≥35 kg/m2) or underweight (bmi ≤18 kg/m2). living in the same household of any covid-19 positive person. any other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol. re-vaccination exclusion criteri. pregnancy. anaphylactic reaction following administration of the investigational vaccine. virologically confirmed cases of sars-cov-2 infection.

history of any other covid-19 investigational/or licensed vaccination. unacceptable laboratory abnormality from screening (prior to first vaccination) or safety testing, as listed below [abnormal complete blood count (cbc), random blood sugar level, renal function test (serum urea and creatinine), liver function tests, urine analysis report, positive serology for hepatitis c or hiv antibody or hepatitis b surface antigen]. (subjects will be informed if their results are positive for hepatitis c, hiv 1 & 2 antibody or hepatitis b surface antigen (hbsag) and will be referred to a primary care provider for follow up of these abnormal laboratory tests.) confirmed sars-cov-2 at the time of screening using rt-pcr and elisa or clia method. history of facial nerve paralysis history of cold, sneezing, nasal obstruction in the past 3 days. prescribed usage of any nasal spray/or nasal drop medication. any significant abnormality altering the anatomy of the nose in a substantial way or nasopharynx that may interfere with the aims of the study and in particular any of the nasal assessments or viral challenge (historical nasal polyps can be included, but large nasal polyps causing current and significant symptoms and/or requiring regular treatments in the last month are excluded) for women of child bearing potential, a positive serum pregnancy test (during screening within 45 days of enrolment) or positive urine pregnancy test (within 24 hours of administering each dose of vaccine). temperature >38.0°c (100.4°f) or symptoms of an acute self-limited illness such as an upper respiratory infection or gastroenteritis within three days prior to each dose of vaccine. medical problems as a result of alcohol or illicit drug use during the past 12 months. receipt of an experimental agent (vaccine, drug, device, etc.) within 60 days before enrolment or expects to receive an investigational agent during the study period. receipt of any licensed vaccine within four weeks before enrolment in this study. known sensitivity to any ingredient of the study vaccines, or a more severe allergic reaction and history of allergies in the past. receipt of immunoglobulin or other blood products within the three months prior to vaccination in this study. immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months. long-term use (> 2 weeks) of oral or parenteral steroids (glucocorticoids) or high-dose inhaled steroids (>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding six months (nasal and topical steroids are allowed). any history of hereditary angioedema or idiopathic angioedema. any history of anaphylaxis in relation to vaccination. any history of albumin-intolerance. pregnancy, lactation, or willingness/intention to become pregnant during the study. history of any cancer. history of severe psychiatric conditions likely to affect participation in the study. a bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder, or prior history of significant bleeding or bruising following im injections or venepuncture. any other serious chronic illness requiring hospital specialist supervision. chronic respiratory diseases like severe acute respiratory syndrome (sars), including mild asthma. chronic cardiovascular disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness morbidly obese (bmi≥35 kg/m2) or underweight (bmi ≤18 kg/m2). living in the same household of any covid-19 positive person. any other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol. re-vaccination exclusion criteri. pregnancy. anaphylactic reaction following administration of the investigational vaccine. virologically confirmed cases of sars-cov-2 infection.

1. history of any other covid-19 investigational/or licensed vaccination. 2. unacceptable laboratory abnormality from screening (prior to first vaccination) or safety testing, as listed below [abnormal complete blood count (cbc), random blood sugar level, renal function test (serum urea and creatinine), liver function tests, urine analysis report, positive serology for hepatitis c or hiv antibody or hepatitis b surface antigen]. (subjects will be informed if their results are positive for hepatitis c, hiv 1 & 2 antibody or hepatitis b surface antigen (hbsag) and will be referred to a primary care provider for follow up of these abnormal laboratory tests.) 3. confirmed sars-cov-2 at the time of screening using rt-pcr and elisa or clia method. 4. history of facial nerve paralysis 5. history of cold, sneezing, nasal obstruction in the past 3 days. 6. prescribed usage of any nasal spray/or nasal drop medication. 7. any significant abnormality altering the anatomy of the nose in a substantial way or nasopharynx that may interfere with the aims of the study and in particular any of the nasal assessments or viral challenge (historical nasal polyps can be included, but large nasal polyps causing current and significant symptoms and/or requiring regular treatments in the last month are excluded) 8. for women of child bearing potential, a positive serum pregnancy test (during screening within 45 days of enrolment) or positive urine pregnancy test (within 24 hours of administering each dose of vaccine). 9. temperature >38.0°c (100.4°f) or symptoms of an acute self-limited illness such as an upper respiratory infection or gastroenteritis within three days prior to each dose of vaccine. 10. medical problems as a result of alcohol or illicit drug use during the past 12 months. 11. receipt of an experimental agent (vaccine, drug, device, etc.) within 60 days before enrolment or expects to receive an investigational agent during the study period. 12. receipt of any licensed vaccine within four weeks before enrolment in this study. 13. known sensitivity to any ingredient of the study vaccines, or a more severe allergic reaction and history of allergies in the past. 14. receipt of immunoglobulin or other blood products within the three months prior to vaccination in this study. 15. immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months. 16. long-term use (> 2 weeks) of oral or parenteral steroids (glucocorticoids) or high-dose inhaled steroids (>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding six months (nasal and topical steroids are allowed). 17. any history of hereditary angioedema or idiopathic angioedema. 18. any history of anaphylaxis in relation to vaccination. 19. any history of albumin-intolerance. 20. pregnancy, lactation, or willingness/intention to become pregnant during the study. 21. history of any cancer. 22. history of severe psychiatric conditions likely to affect participation in the study. 23. a bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder, or prior history of significant bleeding or bruising following im injections or venepuncture. 24. any other serious chronic illness requiring hospital specialist supervision. 25. chronic respiratory diseases like severe acute respiratory syndrome (sars), including mild asthma. 26. chronic cardiovascular disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness 27. morbidly obese (bmi≥35 kg/m2) or underweight (bmi ≤18 kg/m2). 28. living in the same household of any covid-19 positive person. 29. any other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol. re-vaccination exclusion criteri. 30. pregnancy. 31. anaphylactic reaction following administration of the investigational vaccine. 32. virologically confirmed cases of sars-cov-2 infection.

1. history of any other covid-19 investigational/or licensed vaccination. 2. unacceptable laboratory abnormality from screening (prior to first vaccination) or safety testing, as listed below [abnormal complete blood count (cbc), random blood sugar level, renal function test (serum urea and creatinine), liver function tests, urine analysis report, positive serology for hepatitis c or hiv antibody or hepatitis b surface antigen]. (subjects will be informed if their results are positive for hepatitis c, hiv 1 & 2 antibody or hepatitis b surface antigen (hbsag) and will be referred to a primary care provider for follow up of these abnormal laboratory tests.) 3. confirmed sars-cov-2 at the time of screening using rt-pcr and elisa or clia method. 4. history of facial nerve paralysis 5. history of cold, sneezing, nasal obstruction in the past 3 days. 6. prescribed usage of any nasal spray/or nasal drop medication. 7. any significant abnormality altering the anatomy of the nose in a substantial way or nasopharynx that may interfere with the aims of the study and in particular any of the nasal assessments or viral challenge (historical nasal polyps can be included, but large nasal polyps causing current and significant symptoms and/or requiring regular treatments in the last month are excluded) 8. for women of child bearing potential, a positive serum pregnancy test (during screening within 45 days of enrolment) or positive urine pregnancy test (within 24 hours of administering each dose of vaccine). 9. temperature >38.0°c (100.4°f) or symptoms of an acute self-limited illness such as an upper respiratory infection or gastroenteritis within three days prior to each dose of vaccine. 10. medical problems as a result of alcohol or illicit drug use during the past 12 months. 11. receipt of an experimental agent (vaccine, drug, device, etc.) within 60 days before enrolment or expects to receive an investigational agent during the study period. 12. receipt of any licensed vaccine within four weeks before enrolment in this study. 13. known sensitivity to any ingredient of the study vaccines, or a more severe allergic reaction and history of allergies in the past. 14. receipt of immunoglobulin or other blood products within the three months prior to vaccination in this study. 15. immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months. 16. long-term use (> 2 weeks) of oral or parenteral steroids (glucocorticoids) or high-dose inhaled steroids (>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding six months (nasal and topical steroids are allowed). 17. any history of hereditary angioedema or idiopathic angioedema. 18. any history of anaphylaxis in relation to vaccination. 19. any history of albumin-intolerance. 20. pregnancy, lactation, or willingness/intention to become pregnant during the study. 21. history of any cancer. 22. history of severe psychiatric conditions likely to affect participation in the study. 23. a bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder, or prior history of significant bleeding or bruising following im injections or venepuncture. 24. any other serious chronic illness requiring hospital specialist supervision. 25. chronic respiratory diseases like severe acute respiratory syndrome (sars), including mild asthma. 26. chronic cardiovascular disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness 27. morbidly obese (bmi≥35 kg/m2) or underweight (bmi ≤18 kg/m2). 28. living in the same household of any covid-19 positive person. 29. any other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol. re-vaccination exclusion criteri. 30. pregnancy. 31. anaphylactic reaction following administration of the investigational vaccine. 32. virologically confirmed cases of sars-cov-2 infection.