* bed-bound before icu admission * bed-rest order or contraindication of weight load of the lower extremity or spine * severe skin lesions or fasciitis in the area of contact with the device or rhabdomyolysis * fresh sab, icb or elevated icp * status epilepticus * acute intoxication * shock with catecholamine doses \>0.3μg/kg/min or acute bleeding including organ ruptures * multiorgan failure with lactate \> 4 mmol/l * body height outside the range 150-195 cm * body weight outside the range 45-135 kg * pavk iv° * pacemakers or other electrical stimulators * implanted medical pumps * pregnancy * life expectancy below 7 days or acute palliative care situation * death inevitable or maximum therapy is not carried out by the treating physicians or due to patient's request * unable to understand the official language

* bed-bound before icu admission * bed-rest order or contraindication of weight load of the lower extremity or spine * severe skin lesions or fasciitis in the area of contact with the device or rhabdomyolysis * fresh sab, icb or elevated icp * status epilepticus * acute intoxication * shock with catecholamine doses \>0.3μg/kg/min or acute bleeding including organ ruptures * multiorgan failure with lactate \> 4 mmol/l * body height outside the range 150-195 cm * body weight outside the range 45-135 kg * pavk iv° * pacemakers or other electrical stimulators * implanted medical pumps * pregnancy * life expectancy below 7 days or acute palliative care situation * death inevitable or maximum therapy is not carried out by the treating physicians or due to patient's request * unable to understand the official language

- bed-bound before icu admission - bed-rest order or contraindication of weight load of the lower extremity or spine - severe skin lesions or fasciitis in the area of contact with the device or rhabdomyolysis - fresh sab, icb or elevated icp - status epilepticus - acute intoxication - shock with catecholamine doses >0.3μg/kg/min or acute bleeding including organ ruptures - multiorgan failure with lactate > 4 mmol/l - body height outside the range 150-195 cm - body weight outside the range 45-135 kg - pavk iv° - pacemakers or other electrical stimulators - implanted medical pumps - pregnancy - life expectancy below 7 days or acute palliative care situation - death inevitable or maximum therapy is not carried out by the treating physicians or due to patient's request - unable to understand the official language

- bed-bound before icu admission - bed-rest order or contraindication of weight load of the lower extremity or spine - severe skin lesions or fasciitis in the area of contact with the device or rhabdomyolysis - fresh sab, icb or elevated icp - status epilepticus - acute intoxication - shock with catecholamine doses >0.3μg/kg/min or acute bleeding including organ ruptures - multiorgan failure with lactate > 4 mmol/l - body height outside the range 150-195 cm - body weight outside the range 45-135 kg - pavk iv° - pacemakers or other electrical stimulators - implanted medical pumps - pregnancy - life expectancy below 7 days or acute palliative care situation - death inevitable or maximum therapy is not carried out by the treating physicians or due to patient's request - unable to understand the official language

- not able to give consent - bed-bound before icu admission - bed-rest order or contraindication of weight load of the lower extremity or spine - severe skin lesions or fasciitis in the area of contact with the device or rhabdomyolysis - fresh sab, icb or elevated icp - status epilepticus - acute intoxication - shock with catecholamine doses >0.3μg/kg/min or acute bleeding including organ ruptures - multiorgan failure with lactate > 4 mmol/l - body height outside the range 150-195 cm - body weight outside the range 45-135 kg - pavk iv° - pacemakers or other electrical stimulators - implanted medical pumps - pregnancy - life expectancy below 7 days or acute palliative care situation - death inevitable or maximum therapy is not carried out by the treating physicians or due to patient's request - unable to understand the official language - icu stay > 72h at the time of enrolment

- not able to give consent - bed-bound before icu admission - bed-rest order or contraindication of weight load of the lower extremity or spine - severe skin lesions or fasciitis in the area of contact with the device or rhabdomyolysis - fresh sab, icb or elevated icp - status epilepticus - acute intoxication - shock with catecholamine doses >0.3μg/kg/min or acute bleeding including organ ruptures - multiorgan failure with lactate > 4 mmol/l - body height outside the range 150-195 cm - body weight outside the range 45-135 kg - pavk iv° - pacemakers or other electrical stimulators - implanted medical pumps - pregnancy - life expectancy below 7 days or acute palliative care situation - death inevitable or maximum therapy is not carried out by the treating physicians or due to patient's request - unable to understand the official language - icu stay > 72h at the time of enrolment