1. known allergy to any of the ingredients or components of the investigational product 2. known pregnancy 3. moribund and not expected to survive beyond 24 hours 4. known or suspected risk for serious bleeding complications (note that disseminated intravascular coagulopathy (dic) is an expected finding in patient with sepsis and covid-19 disease and is not an exclusion criterion on its own) 5. acute or chronic renal failure (dialysis dependent)

1. known allergy to any of the ingredients or components of the investigational product 2. known pregnancy 3. moribund and not expected to survive beyond 24 hours 4. known or suspected risk for serious bleeding complications (note that disseminated intravascular coagulopathy (dic) is an expected finding in patient with sepsis and covid-19 disease and is not an exclusion criterion on its own) 5. acute or chronic renal failure (dialysis dependent)

known allergy to any of the ingredients or components of the investigational product known pregnancy moribund and not expected to survive beyond 24 hours known or suspected risk for serious bleeding complications (note that disseminated intravascular coagulopathy (dic) is an expected finding in patient with sepsis and covid-19 disease and is not an exclusion criterion on its own) acute or chronic renal failure (dialysis dependent)

known allergy to any of the ingredients or components of the investigational product known pregnancy moribund and not expected to survive beyond 24 hours known or suspected risk for serious bleeding complications (note that disseminated intravascular coagulopathy (dic) is an expected finding in patient with sepsis and covid-19 disease and is not an exclusion criterion on its own) acute or chronic renal failure (dialysis dependent)

1. known allergy to any of the ingredients or components of the investigational product 2. known pregnancy 3. moribund and not expected to survive beyond 24 hours 4. known or suspected risk for serious bleeding complications (note that disseminated intravascular coagulopathy (dic) is an expected finding in patient with sepsis and covid-19 disease and is not an exclusion criterion on its own) 5. acute or chronic renal failure (dialysis dependent)

1. known allergy to any of the ingredients or components of the investigational product 2. known pregnancy 3. moribund and not expected to survive beyond 24 hours 4. known or suspected risk for serious bleeding complications (note that disseminated intravascular coagulopathy (dic) is an expected finding in patient with sepsis and covid-19 disease and is not an exclusion criterion on its own) 5. acute or chronic renal failure (dialysis dependent)