inclusion criteria: 1. at least 65 years old, at least 75 years old or 18 to 45 years old, depending on the group of inclusion. 2. healthy adults, or stable medical condition for adults with pre-existing medical conditions. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during 3 months before enrolment, nor expected to require any significant change in therapy or hospitalization for worsening disease in foreseeable future. 3. understands and agrees to comply with the study procedures (visits, phone calls) and provides written free informed consent. 4. able to comply with study procedures based on investigator judgement. 5. affiliated to a social security system, (except state medical aid)

inclusion criteria: 1. at least 65 years old, at least 75 years old or 18 to 45 years old, depending on the group of inclusion. 2. healthy adults, or stable medical condition for adults with pre-existing medical conditions. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during 3 months before enrolment, nor expected to require any significant change in therapy or hospitalization for worsening disease in foreseeable future. 3. understands and agrees to comply with the study procedures (visits, phone calls) and provides written free informed consent. 4. able to comply with study procedures based on investigator judgement. 5. affiliated to a social security system, (except state medical aid)

inclusion criteria: at least 65 years old, at least 75 years old or 18 to 45 years old, depending on the group of inclusion. healthy adults, or stable medical condition for adults with pre-existing medical conditions. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during 3 months before enrolment, nor expected to require any significant change in therapy or hospitalization for worsening disease in foreseeable future. understands and agrees to comply with the study procedures (visits, phone calls) and provides written free informed consent. able to comply with study procedures based on investigator judgement. affiliated to a social security system, (except state medical aid)

inclusion criteria: at least 65 years old, at least 75 years old or 18 to 45 years old, depending on the group of inclusion. healthy adults, or stable medical condition for adults with pre-existing medical conditions. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during 3 months before enrolment, nor expected to require any significant change in therapy or hospitalization for worsening disease in foreseeable future. understands and agrees to comply with the study procedures (visits, phone calls) and provides written free informed consent. able to comply with study procedures based on investigator judgement. affiliated to a social security system, (except state medical aid)

inclusion criteria: 1. at least 65 years old, at least 75 years old or 18 to 45 years old, depending on the group of inclusion. 2. healthy adults, or stable medical condition for adults with pre-existing medical conditions. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during 3 months before enrolment, nor expected to require any significant change in therapy or hospitalization for worsening disease in foreseeable future. 3. understands and agrees to comply with the study procedures (visits, phone calls) and provides written free informed consent. 4. able to comply with study procedures based on investigator judgement. 5. affiliated to a social security system, (except state medical aid)

inclusion criteria: 1. at least 65 years old, at least 75 years old or 18 to 45 years old, depending on the group of inclusion. 2. healthy adults, or stable medical condition for adults with pre-existing medical conditions. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during 3 months before enrolment, nor expected to require any significant change in therapy or hospitalization for worsening disease in foreseeable future. 3. understands and agrees to comply with the study procedures (visits, phone calls) and provides written free informed consent. 4. able to comply with study procedures based on investigator judgement. 5. affiliated to a social security system, (except state medical aid)