1. alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) \>5 times the upper limit of normal (uln) 2. stage 4 severe chronic kidney disease or requiring dialysis (i.e., estimated glomerular filtration rate \<30 ml/min/1.73 m\^2) 3. pregnant or breast feeding 4. anticipated transfer to another hospital which is not a study site within 72 hours 5. allergy to any study medication 6. patients taking other prohibited drugs (as outline in cst protocol) within 30 days or 5 times the half-life (whichever is longer) of enrolment 7. patients participating in another ctimp trial n.b. the cst protocol exclusion criteria will take precedence over the master protocol exclusion criteria. cst-2

1. alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) \>5 times the upper limit of normal (uln) 2. stage 4 severe chronic kidney disease or requiring dialysis (i.e., estimated glomerular filtration rate \<30 ml/min/1.73 m\^2) 3. pregnant or breast feeding 4. anticipated transfer to another hospital which is not a study site within 72 hours 5. allergy to any study medication 6. patients taking other prohibited drugs (as outline in cst protocol) within 30 days or 5 times the half-life (whichever is longer) of enrolment 7. patients participating in another ctimp trial n.b. the cst protocol exclusion criteria will take precedence over the master protocol exclusion criteria. cst-2

alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) >5 times the upper limit of normal (uln) stage 4 severe chronic kidney disease or requiring dialysis (i.e., estimated glomerular filtration rate <30 ml/min/1.73 m^2) pregnant or breast feeding anticipated transfer to another hospital which is not a study site within 72 hours allergy to any study medication patients taking other prohibited drugs (as outline in cst protocol) within 30 days or 5 times the half-life (whichever is longer) of enrolment patients participating in another ctimp trial n.b. the cst protocol exclusion criteria will take precedence over the master protocol exclusion criteria. cst-2

alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) >5 times the upper limit of normal (uln) stage 4 severe chronic kidney disease or requiring dialysis (i.e., estimated glomerular filtration rate <30 ml/min/1.73 m^2) pregnant or breast feeding anticipated transfer to another hospital which is not a study site within 72 hours allergy to any study medication patients taking other prohibited drugs (as outline in cst protocol) within 30 days or 5 times the half-life (whichever is longer) of enrolment patients participating in another ctimp trial n.b. the cst protocol exclusion criteria will take precedence over the master protocol exclusion criteria. cst-2

1. alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) >5 times the upper limit of normal (uln) 2. stage 4 severe chronic kidney disease or requiring dialysis (i.e., estimated glomerular filtration rate <30 ml/min/1.73 m^2) 3. pregnant or breast feeding 4. anticipated transfer to another hospital which is not a study site within 72 hours 5. allergy to any study medication 6. patients taking other prohibited drugs (as outline in cst protocol) within 30 days or 5 times the half-life (whichever is longer) of enrolment 7. patients participating in another ctimp trial n.b. the cst protocol exclusion criteria will take precedence over the master protocol exclusion criteria. cst-2

1. alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) >5 times the upper limit of normal (uln) 2. stage 4 severe chronic kidney disease or requiring dialysis (i.e., estimated glomerular filtration rate <30 ml/min/1.73 m^2) 3. pregnant or breast feeding 4. anticipated transfer to another hospital which is not a study site within 72 hours 5. allergy to any study medication 6. patients taking other prohibited drugs (as outline in cst protocol) within 30 days or 5 times the half-life (whichever is longer) of enrolment 7. patients participating in another ctimp trial n.b. the cst protocol exclusion criteria will take precedence over the master protocol exclusion criteria. cst-2