inclusion criteria: * age \>= 18 and \< 85 years * covid-19 diagnosis confirmed. * radiological image compatible with covid-19 * present any of the following clinical-functional criteria considered risk: 1. respiratory distress: tachypnea \> 26 breaths / minute 2. pao2 / fio2 oxygenation index # 300 3. alteration of one or more of the following parameters: c.i. dd\> 1,000 µg / l c.ii. ferritin\> 800 ng / ml 4.c.iii. lymphocytes \<800 cells / µl 4.c.iv. pcr\> 100 mg / l 4.c.v. ldh\> 500 u / l c.vi. il-6\> 15 pg / ml * direct or delegated verbal informed consent

inclusion criteria: * age \>= 18 and \< 85 years * covid-19 diagnosis confirmed. * radiological image compatible with covid-19 * present any of the following clinical-functional criteria considered risk: 1. respiratory distress: tachypnea \> 26 breaths / minute 2. pao2 / fio2 oxygenation index # 300 3. alteration of one or more of the following parameters: c.i. dd\> 1,000 µg / l c.ii. ferritin\> 800 ng / ml 4.c.iii. lymphocytes \<800 cells / µl 4.c.iv. pcr\> 100 mg / l 4.c.v. ldh\> 500 u / l c.vi. il-6\> 15 pg / ml * direct or delegated verbal informed consent

inclusion criteria: age >= 18 and < 85 years covid-19 diagnosis confirmed. radiological image compatible with covid-19 present any of the following clinical-functional criteria considered risk: respiratory distress: tachypnea > 26 breaths / minute pao2 / fio2 oxygenation index # 300 alteration of one or more of the following parameters: c.i. dd> 1,000 µg / l c.ii. ferritin> 800 ng / ml 4.c.iii. lymphocytes <800 cells / µl 4.c.iv. pcr> 100 mg / l 4.c.v. ldh> 500 u / l c.vi. il-6> 15 pg / ml direct or delegated verbal informed consent

inclusion criteria: age >= 18 and < 85 years covid-19 diagnosis confirmed. radiological image compatible with covid-19 present any of the following clinical-functional criteria considered risk: respiratory distress: tachypnea > 26 breaths / minute pao2 / fio2 oxygenation index # 300 alteration of one or more of the following parameters: c.i. dd> 1,000 µg / l c.ii. ferritin> 800 ng / ml 4.c.iii. lymphocytes <800 cells / µl 4.c.iv. pcr> 100 mg / l 4.c.v. ldh> 500 u / l c.vi. il-6> 15 pg / ml direct or delegated verbal informed consent

inclusion criteria: - age >= 18 and < 85 years - covid-19 diagnosis confirmed. - radiological image compatible with covid-19 - present any of the following clinical-functional criteria considered risk: 1. respiratory distress: tachypnea > 26 breaths / minute 2. pao2 / fio2 oxygenation index # 300 3. alteration of one or more of the following parameters: c.i. dd> 1,000 µg / l c.ii. ferritin> 800 ng / ml 4.c.iii. lymphocytes <800 cells / µl 4.c.iv. pcr> 100 mg / l 4.c.v. ldh> 500 u / l c.vi. il-6> 15 pg / ml - direct or delegated verbal informed consent

inclusion criteria: - age >= 18 and < 85 years - covid-19 diagnosis confirmed. - radiological image compatible with covid-19 - present any of the following clinical-functional criteria considered risk: 1. respiratory distress: tachypnea > 26 breaths / minute 2. pao2 / fio2 oxygenation index # 300 3. alteration of one or more of the following parameters: c.i. dd> 1,000 µg / l c.ii. ferritin> 800 ng / ml 4.c.iii. lymphocytes <800 cells / µl 4.c.iv. pcr> 100 mg / l 4.c.v. ldh> 500 u / l c.vi. il-6> 15 pg / ml - direct or delegated verbal informed consent