key inclusion criteria: * severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive as determined by polymerase chain reaction (pcr) or other commercially available or public health assay (eg, nucleic acid amplification test (naat) and antigen tests) in any respiratory specimen * hospitalized for covid-19 * weighing at least 40 kilograms (kg) * oxygen (o2) saturation ≤ 94% on room air or requiring o2 supplement or radiographic evidence of pulmonary infiltrates for covid-19 * have either: * a) severely reduced kidney function (estimated glomerular filtration rate (egfr) \< 30 ml/min/1.73 m\^2), including people with end-stage kidney disease (eskd) requiring chronic dialysis * b) ongoing acute kidney injury (aki): defined as a 50% increase in serum creatinine (scr) within a 48-hour period that is sustained (ie, requires confirmatory scr) for ≥ 6 hours despite supportive care * the interval between covid-19 symptoms onset and randomization is no more than 10 days key

key inclusion criteria: * severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive as determined by polymerase chain reaction (pcr) or other commercially available or public health assay (eg, nucleic acid amplification test (naat) and antigen tests) in any respiratory specimen * hospitalized for covid-19 * weighing at least 40 kilograms (kg) * oxygen (o2) saturation ≤ 94% on room air or requiring o2 supplement or radiographic evidence of pulmonary infiltrates for covid-19 * have either: * a) severely reduced kidney function (estimated glomerular filtration rate (egfr) \< 30 ml/min/1.73 m\^2), including people with end-stage kidney disease (eskd) requiring chronic dialysis * b) ongoing acute kidney injury (aki): defined as a 50% increase in serum creatinine (scr) within a 48-hour period that is sustained (ie, requires confirmatory scr) for ≥ 6 hours despite supportive care * the interval between covid-19 symptoms onset and randomization is no more than 10 days key

key inclusion criteria: - severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive as determined by polymerase chain reaction (pcr) or other commercially available or public health assay (eg, nucleic acid amplification test (naat) and antigen tests) in any respiratory specimen - hospitalized for covid-19 - weighing at least 40 kilograms (kg) - oxygen (o2) saturation ≤ 94% on room air or requiring o2 supplement or radiographic evidence of pulmonary infiltrates for covid-19 - have either: - a) severely reduced kidney function (estimated glomerular filtration rate (egfr) < 30 ml/min/1.73 m^2), including people with end-stage kidney disease (eskd) requiring chronic dialysis - b) ongoing acute kidney injury (aki): defined as a 50% increase in serum creatinine (scr) within a 48-hour period that is sustained (ie, requires confirmatory scr) for ≥ 6 hours despite supportive care - the interval between covid-19 symptoms onset and randomization is no more than 10 days key

key inclusion criteria: - severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive as determined by polymerase chain reaction (pcr) or other commercially available or public health assay (eg, nucleic acid amplification test (naat) and antigen tests) in any respiratory specimen - hospitalized for covid-19 - weighing at least 40 kilograms (kg) - oxygen (o2) saturation ≤ 94% on room air or requiring o2 supplement or radiographic evidence of pulmonary infiltrates for covid-19 - have either: - a) severely reduced kidney function (estimated glomerular filtration rate (egfr) < 30 ml/min/1.73 m^2), including people with end-stage kidney disease (eskd) requiring chronic dialysis - b) ongoing acute kidney injury (aki): defined as a 50% increase in serum creatinine (scr) within a 48-hour period that is sustained (ie, requires confirmatory scr) for ≥ 6 hours despite supportive care - the interval between covid-19 symptoms onset and randomization is no more than 10 days key

key inclusion criteria: - severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive as determined by polymerase chain reaction (pcr) or other commercially available or public health assay (eg, nucleic acid amplification test (naat) and antigen tests) in any respiratory specimen - hospitalized for covid-19 - weighing at least 40 kilograms (kg) - oxygen (o2) saturation ≤ 94% on room air or requiring o2 supplement or radiographic evidence of pulmonary infiltrates for covid-19 - severely reduced kidney function (estimated glomerular filtration rate (egfr) < 30 ml/min/1.73 m^2), including people with end-stage kidney disease (eskd) requiring chronic dialysis - the interval between covid-19 symptoms onset and randomization is no more than 10 days key

key inclusion criteria: - severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive as determined by polymerase chain reaction (pcr) or other commercially available or public health assay (eg, nucleic acid amplification test (naat) and antigen tests) in any respiratory specimen - hospitalized for covid-19 - weighing at least 40 kilograms (kg) - oxygen (o2) saturation ≤ 94% on room air or requiring o2 supplement or radiographic evidence of pulmonary infiltrates for covid-19 - severely reduced kidney function (estimated glomerular filtration rate (egfr) < 30 ml/min/1.73 m^2), including people with end-stage kidney disease (eskd) requiring chronic dialysis - the interval between covid-19 symptoms onset and randomization is no more than 10 days key

key inclusion criteria: - severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive as determined by polymerase chain reaction (pcr) or other commercially available or public health assay (eg, nucleic acid amplification test [naat] and antigen tests) in any respiratory specimen - hospitalized for covid-19 - weighing at least 40 kilograms (kg) - oxygen (o2) saturation ≤ 94% on room air or requiring o2 supplement or radiographic evidence of pulmonary infiltrates for covid-19 - severely reduced kidney function (estimated glomerular filtration rate [egfr] < 30 milliliters per minute per 1.73 square meters [ml/min/1.73 m^2]), including people with eskd requiring chronic dialysis - the interval between covid-19 symptoms onset and randomization is no more than 10 days key

key inclusion criteria: - severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive as determined by polymerase chain reaction (pcr) or other commercially available or public health assay (eg, nucleic acid amplification test [naat] and antigen tests) in any respiratory specimen - hospitalized for covid-19 - weighing at least 40 kilograms (kg) - oxygen (o2) saturation ≤ 94% on room air or requiring o2 supplement or radiographic evidence of pulmonary infiltrates for covid-19 - severely reduced kidney function (estimated glomerular filtration rate [egfr] < 30 milliliters per minute per 1.73 square meters [ml/min/1.73 m^2]), including people with eskd requiring chronic dialysis - the interval between covid-19 symptoms onset and randomization is no more than 10 days key