inclusion criteria: 1. male or female, 18 years old ≤ age ≤ 75years old; 2. ct image is characteristic of 2019 novel coronavirus pneumonia; 3. laboratory confirmation of 2019-ncov infection by reverse transcription polymerase chain reaction (rt-pcr); 4. in compliance with the 2019-ncov pneumonia diagnosis standard (according to the novel coronavirus infection pneumonia diagnosis and treatment program (trial implementation version 6) issued by the national health and medical commission, and who 2019 new coronavirus guidelines standards): (a) increased breathing rate (≥30 beats / min), difficulty breathing, cyanosis of the lips; (b) in resting state, means oxygen saturation ≤93%; (c) partial pressure of arterial oxygen (pao2) / fraction of inspired oxygen (fio2) ≤300 mmhg (1mmhg = 0.133kpa); 5. participant or the authorized agent signed the informed consent form. 6. agree to collect clinical samples.

inclusion criteria: 1. male or female, 18 years old ≤ age ≤ 75years old; 2. ct image is characteristic of 2019 novel coronavirus pneumonia; 3. laboratory confirmation of 2019-ncov infection by reverse transcription polymerase chain reaction (rt-pcr); 4. in compliance with the 2019-ncov pneumonia diagnosis standard (according to the novel coronavirus infection pneumonia diagnosis and treatment program (trial implementation version 6) issued by the national health and medical commission, and who 2019 new coronavirus guidelines standards): (a) increased breathing rate (≥30 beats / min), difficulty breathing, cyanosis of the lips; (b) in resting state, means oxygen saturation ≤93%; (c) partial pressure of arterial oxygen (pao2) / fraction of inspired oxygen (fio2) ≤300 mmhg (1mmhg = 0.133kpa); 5. participant or the authorized agent signed the informed consent form. 6. agree to collect clinical samples.

inclusion criteria: male or female, 18 years old ≤ age ≤ 75years old; ct image is characteristic of 2019 novel coronavirus pneumonia; laboratory confirmation of 2019-ncov infection by reverse transcription polymerase chain reaction (rt-pcr); in compliance with the 2019-ncov pneumonia diagnosis standard (according to the novel coronavirus infection pneumonia diagnosis and treatment program (trial implementation version 6) issued by the national health and medical commission, and who 2019 new coronavirus guidelines standards): (a) increased breathing rate (≥30 beats / min), difficulty breathing, cyanosis of the lips; (b) in resting state, means oxygen saturation ≤93%; (c) partial pressure of arterial oxygen (pao2) / fraction of inspired oxygen (fio2) ≤300 mmhg (1mmhg = 0.133kpa); participant or the authorized agent signed the informed consent form. agree to collect clinical samples.

inclusion criteria: male or female, 18 years old ≤ age ≤ 75years old; ct image is characteristic of 2019 novel coronavirus pneumonia; laboratory confirmation of 2019-ncov infection by reverse transcription polymerase chain reaction (rt-pcr); in compliance with the 2019-ncov pneumonia diagnosis standard (according to the novel coronavirus infection pneumonia diagnosis and treatment program (trial implementation version 6) issued by the national health and medical commission, and who 2019 new coronavirus guidelines standards): (a) increased breathing rate (≥30 beats / min), difficulty breathing, cyanosis of the lips; (b) in resting state, means oxygen saturation ≤93%; (c) partial pressure of arterial oxygen (pao2) / fraction of inspired oxygen (fio2) ≤300 mmhg (1mmhg = 0.133kpa); participant or the authorized agent signed the informed consent form. agree to collect clinical samples.

inclusion criteria: 1. male or female, 18 years old ≤ age ≤ 75years old; 2. ct image is characteristic of 2019 novel coronavirus pneumonia; 3. laboratory confirmation of 2019-ncov infection by reverse transcription polymerase chain reaction (rt-pcr); 4. in compliance with the 2019-ncov pneumonia diagnosis standard (according to the novel coronavirus infection pneumonia diagnosis and treatment program (trial implementation version 6) issued by the national health and medical commission, and who 2019 new coronavirus guidelines standards): (a) increased breathing rate (≥30 beats / min), difficulty breathing, cyanosis of the lips; (b) in resting state, means oxygen saturation ≤93%; (c) partial pressure of arterial oxygen (pao2) / fraction of inspired oxygen (fio2) ≤300 mmhg (1mmhg = 0.133kpa); 5. participant or the authorized agent signed the informed consent form. 6. agree to collect clinical samples.

inclusion criteria: 1. male or female, 18 years old ≤ age ≤ 75years old; 2. ct image is characteristic of 2019 novel coronavirus pneumonia; 3. laboratory confirmation of 2019-ncov infection by reverse transcription polymerase chain reaction (rt-pcr); 4. in compliance with the 2019-ncov pneumonia diagnosis standard (according to the novel coronavirus infection pneumonia diagnosis and treatment program (trial implementation version 6) issued by the national health and medical commission, and who 2019 new coronavirus guidelines standards): (a) increased breathing rate (≥30 beats / min), difficulty breathing, cyanosis of the lips; (b) in resting state, means oxygen saturation ≤93%; (c) partial pressure of arterial oxygen (pao2) / fraction of inspired oxygen (fio2) ≤300 mmhg (1mmhg = 0.133kpa); 5. participant or the authorized agent signed the informed consent form. 6. agree to collect clinical samples.