1. pregnant (positive β-human chorionic gonadotropin test, β-hcg) or lactating female at screening. 2. patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants. 3. patients admitted in icu. 4. taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study. 5. history of glucose-6-phosphate dehydrogenase deficiency. 6. pre-treatment corrected qt interval (qtc) ≥450 milliseconds. 7. acute or chronic kidney disease (stage-4 or -5 renal impairment; egfr\<30 ml/min/1.73 m2 or hemodialysis). 8. liver child-pugh grade c. 9. patients with hypokalemia (\<3.6 mg/dl), hypocalcemia (\<8.8 mg/dl), hypomagnesemia (\<1.7 mg/dl). will be included after correction. 10. need for mechanical ventilation. 11. history of hypersensitivity to hydroxychloroquine. 12. history of chronic hepatitis b or hepatitis c infections. 13. history of human immunodeficiency virus (hiv) infection. 14. concurrent serious illness including, but not limited to, any of the following: * clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina). * new york heart association class ii-iv congestive heart failure. * serious cardiac arrhythmia requiring medication. * peripheral vascular disease ≥ grade 2 within the past year. * psychiatric illness/social situation that would limit compliance with study requirements. * copd, lung cancer, and moderate to severe asthma. 15. any other significant finding based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 16. any other concomitant treatment based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 17. is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 80 days of signing the informed consent/assent for this current trial.

1. pregnant (positive β-human chorionic gonadotropin test, β-hcg) or lactating female at screening. 2. patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants. 3. patients admitted in icu. 4. taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study. 5. history of glucose-6-phosphate dehydrogenase deficiency. 6. pre-treatment corrected qt interval (qtc) ≥450 milliseconds. 7. acute or chronic kidney disease (stage-4 or -5 renal impairment; egfr\<30 ml/min/1.73 m2 or hemodialysis). 8. liver child-pugh grade c. 9. patients with hypokalemia (\<3.6 mg/dl), hypocalcemia (\<8.8 mg/dl), hypomagnesemia (\<1.7 mg/dl). will be included after correction. 10. need for mechanical ventilation. 11. history of hypersensitivity to hydroxychloroquine. 12. history of chronic hepatitis b or hepatitis c infections. 13. history of human immunodeficiency virus (hiv) infection. 14. concurrent serious illness including, but not limited to, any of the following: * clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina). * new york heart association class ii-iv congestive heart failure. * serious cardiac arrhythmia requiring medication. * peripheral vascular disease ≥ grade 2 within the past year. * psychiatric illness/social situation that would limit compliance with study requirements. * copd, lung cancer, and moderate to severe asthma. 15. any other significant finding based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 16. any other concomitant treatment based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 17. is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 80 days of signing the informed consent/assent for this current trial.

pregnant (positive β-human chorionic gonadotropin test, β-hcg) or lactating female at screening. patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants. patients admitted in icu. taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study. history of glucose-6-phosphate dehydrogenase deficiency. pre-treatment corrected qt interval (qtc) ≥450 milliseconds. acute or chronic kidney disease (stage-4 or -5 renal impairment; egfr<30 ml/min/1.73 m2 or hemodialysis). liver child-pugh grade c. patients with hypokalemia (<3.6 mg/dl), hypocalcemia (<8.8 mg/dl), hypomagnesemia (<1.7 mg/dl). will be included after correction. need for mechanical ventilation. history of hypersensitivity to hydroxychloroquine. history of chronic hepatitis b or hepatitis c infections. history of human immunodeficiency virus (hiv) infection. concurrent serious illness including, but not limited to, any of the following: clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina). new york heart association class ii-iv congestive heart failure. serious cardiac arrhythmia requiring medication. peripheral vascular disease ≥ grade 2 within the past year. psychiatric illness/social situation that would limit compliance with study requirements. copd, lung cancer, and moderate to severe asthma. any other significant finding based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. any other concomitant treatment based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 80 days of signing the informed consent/assent for this current trial.

pregnant (positive β-human chorionic gonadotropin test, β-hcg) or lactating female at screening. patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants. patients admitted in icu. taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study. history of glucose-6-phosphate dehydrogenase deficiency. pre-treatment corrected qt interval (qtc) ≥450 milliseconds. acute or chronic kidney disease (stage-4 or -5 renal impairment; egfr<30 ml/min/1.73 m2 or hemodialysis). liver child-pugh grade c. patients with hypokalemia (<3.6 mg/dl), hypocalcemia (<8.8 mg/dl), hypomagnesemia (<1.7 mg/dl). will be included after correction. need for mechanical ventilation. history of hypersensitivity to hydroxychloroquine. history of chronic hepatitis b or hepatitis c infections. history of human immunodeficiency virus (hiv) infection. concurrent serious illness including, but not limited to, any of the following: clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina). new york heart association class ii-iv congestive heart failure. serious cardiac arrhythmia requiring medication. peripheral vascular disease ≥ grade 2 within the past year. psychiatric illness/social situation that would limit compliance with study requirements. copd, lung cancer, and moderate to severe asthma. any other significant finding based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. any other concomitant treatment based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 80 days of signing the informed consent/assent for this current trial.

1. pregnant (positive β-human chorionic gonadotropin test, β-hcg) or lactating female at screening. 2. patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants. 3. patients admitted in icu. 4. taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study. 5. history of glucose-6-phosphate dehydrogenase deficiency. 6. pre-treatment corrected qt interval (qtc) ≥450 milliseconds. 7. acute or chronic kidney disease (stage-4 or -5 renal impairment; egfr<30 ml/min/1.73 m2 or hemodialysis). 8. liver child-pugh grade c. 9. patients with hypokalemia (<3.6 mg/dl), hypocalcemia (<8.8 mg/dl), hypomagnesemia (<1.7 mg/dl). will be included after correction. 10. need for mechanical ventilation. 11. history of hypersensitivity to hydroxychloroquine. 12. history of chronic hepatitis b or hepatitis c infections. 13. history of human immunodeficiency virus (hiv) infection. 14. concurrent serious illness including, but not limited to, any of the following: - clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina). - new york heart association class ii-iv congestive heart failure. - serious cardiac arrhythmia requiring medication. - peripheral vascular disease ≥ grade 2 within the past year. - psychiatric illness/social situation that would limit compliance with study requirements. - copd, lung cancer, and moderate to severe asthma. 15. any other significant finding based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 16. any other concomitant treatment based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 17. is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 80 days of signing the informed consent/assent for this current trial.

1. pregnant (positive β-human chorionic gonadotropin test, β-hcg) or lactating female at screening. 2. patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants. 3. patients admitted in icu. 4. taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study. 5. history of glucose-6-phosphate dehydrogenase deficiency. 6. pre-treatment corrected qt interval (qtc) ≥450 milliseconds. 7. acute or chronic kidney disease (stage-4 or -5 renal impairment; egfr<30 ml/min/1.73 m2 or hemodialysis). 8. liver child-pugh grade c. 9. patients with hypokalemia (<3.6 mg/dl), hypocalcemia (<8.8 mg/dl), hypomagnesemia (<1.7 mg/dl). will be included after correction. 10. need for mechanical ventilation. 11. history of hypersensitivity to hydroxychloroquine. 12. history of chronic hepatitis b or hepatitis c infections. 13. history of human immunodeficiency virus (hiv) infection. 14. concurrent serious illness including, but not limited to, any of the following: - clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina). - new york heart association class ii-iv congestive heart failure. - serious cardiac arrhythmia requiring medication. - peripheral vascular disease ≥ grade 2 within the past year. - psychiatric illness/social situation that would limit compliance with study requirements. - copd, lung cancer, and moderate to severe asthma. 15. any other significant finding based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 16. any other concomitant treatment based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 17. is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 80 days of signing the informed consent/assent for this current trial.

1. pregnant (positive β-human chorionic gonadotropin test, β-hcg) or lactating female at screening. 2. patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, uncontrolled systemic bacterial or fungal infections, active viral infection other than covid-19, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants. 3. patients admitted in icu. 4. taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, , statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study. 5. glucose-6-phosphate dehydrogenase deficiency. 6. pre-treatment corrected qt interval (qtc) ≥450 milliseconds. 7. acute or chronic kidney disease (stage-4 or -5 renal impairment; egfr<30 ml/min/1.73 m2 or hemodialysis). 8. liver child-pugh grade c. 9. patients with hypokalemia (<3.5 mg/dl), hypocalcemia (<8.0 mg/dl), hypomagnesemia (<1.6mg/dl) will be included after correction. 10. need for mechanical ventilation. 11. history of hypersensitivity to hydroxychloroquine. 12. chronic hepatitis b or hepatitis c infections. 13. human immunodeficiency virus (hiv) infection. 14. no concurrent serious illness including, but not limited to, any of the following: - clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina). - new york heart association class ii-iv congestive heart failure. - serious cardiac arrhythmia requiring medication. - peripheral vascular disease ≥ grade 2 within the past year. - psychiatric illness/social situation that would limit compliance with study requirements. 15. any other significant finding based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 16. any other concomitant treatment based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study.

1. pregnant (positive β-human chorionic gonadotropin test, β-hcg) or lactating female at screening. 2. patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, uncontrolled systemic bacterial or fungal infections, active viral infection other than covid-19, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants. 3. patients admitted in icu. 4. taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, , statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study. 5. glucose-6-phosphate dehydrogenase deficiency. 6. pre-treatment corrected qt interval (qtc) ≥450 milliseconds. 7. acute or chronic kidney disease (stage-4 or -5 renal impairment; egfr<30 ml/min/1.73 m2 or hemodialysis). 8. liver child-pugh grade c. 9. patients with hypokalemia (<3.5 mg/dl), hypocalcemia (<8.0 mg/dl), hypomagnesemia (<1.6mg/dl) will be included after correction. 10. need for mechanical ventilation. 11. history of hypersensitivity to hydroxychloroquine. 12. chronic hepatitis b or hepatitis c infections. 13. human immunodeficiency virus (hiv) infection. 14. no concurrent serious illness including, but not limited to, any of the following: - clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina). - new york heart association class ii-iv congestive heart failure. - serious cardiac arrhythmia requiring medication. - peripheral vascular disease ≥ grade 2 within the past year. - psychiatric illness/social situation that would limit compliance with study requirements. 15. any other significant finding based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study. 16. any other concomitant treatment based on the judgment of the pi would increase the risk of having an adverse outcome from participating in this study.