inclusion criteria: 1. patients admitted to hospital with covid-19, pcr and/or antigens test + sars-cov-2 infection or (presence of infiltrate compatible with chest x-ray or tc) 2. patients with, at least, one of the following evolution disease risk criteria: * sat 02\<94% * need for oxygen therapy or pao2/fio2\<300mmhg or estimated pao2/fio2 based on spo2/fio2\<300 mmhg. * dd\>1000µg/l * pcr \>150mg/l * il6 \>40pg/ml 3. age \> 18 years 4. weight 50-100 kg 5. after receiving oral and written information about the study, patient must give informed consent duly signed and dated before performing any activity related to the study.

inclusion criteria: 1. patients admitted to hospital with covid-19, pcr and/or antigens test + sars-cov-2 infection or (presence of infiltrate compatible with chest x-ray or tc) 2. patients with, at least, one of the following evolution disease risk criteria: * sat 02\<94% * need for oxygen therapy or pao2/fio2\<300mmhg or estimated pao2/fio2 based on spo2/fio2\<300 mmhg. * dd\>1000µg/l * pcr \>150mg/l * il6 \>40pg/ml 3. age \> 18 years 4. weight 50-100 kg 5. after receiving oral and written information about the study, patient must give informed consent duly signed and dated before performing any activity related to the study.

inclusion criteria: patients admitted to hospital with covid-19, pcr and/or antigens test + sars-cov-2 infection or (presence of infiltrate compatible with chest x-ray or tc) patients with, at least, one of the following evolution disease risk criteria: sat 02<94% need for oxygen therapy or pao2/fio2<300mmhg or estimated pao2/fio2 based on spo2/fio2<300 mmhg. dd>1000µg/l pcr >150mg/l il6 >40pg/ml age > 18 years weight 50-100 kg after receiving oral and written information about the study, patient must give informed consent duly signed and dated before performing any activity related to the study.

inclusion criteria: patients admitted to hospital with covid-19, pcr and/or antigens test + sars-cov-2 infection or (presence of infiltrate compatible with chest x-ray or tc) patients with, at least, one of the following evolution disease risk criteria: sat 02<94% need for oxygen therapy or pao2/fio2<300mmhg or estimated pao2/fio2 based on spo2/fio2<300 mmhg. dd>1000µg/l pcr >150mg/l il6 >40pg/ml age > 18 years weight 50-100 kg after receiving oral and written information about the study, patient must give informed consent duly signed and dated before performing any activity related to the study.

inclusion criteria: 1. patients admitted to hospital with covid-19, pcr and/or antigens test + sars-cov-2 infection or (presence of infiltrate compatible with chest x-ray or tc) 2. patients with, at least, one of the following evolution disease risk criteria: - sat 02<94% - need for oxygen therapy or pao2/fio2<300mmhg or estimated pao2/fio2 based on spo2/fio2<300 mmhg. - dd>1000µg/l - pcr >150mg/l - il6 >40pg/ml 3. age > 18 years 4. weight 50-100 kg 5. after receiving oral and written information about the study, patient must give informed consent duly signed and dated before performing any activity related to the study.

inclusion criteria: 1. patients admitted to hospital with covid-19, pcr and/or antigens test + sars-cov-2 infection or (presence of infiltrate compatible with chest x-ray or tc) 2. patients with, at least, one of the following evolution disease risk criteria: - sat 02<94% - need for oxygen therapy or pao2/fio2<300mmhg or estimated pao2/fio2 based on spo2/fio2<300 mmhg. - dd>1000µg/l - pcr >150mg/l - il6 >40pg/ml 3. age > 18 years 4. weight 50-100 kg 5. after receiving oral and written information about the study, patient must give informed consent duly signed and dated before performing any activity related to the study.

inclusion criteria: 1. patients admitted to hospital with covid-19, pcr + sars-cov-2 infection or (presence of infiltrate compatible with chest x-ray or tc) 2. patients with, at least, one of the following evolution disease risk criteria: - sat 02<94% - need for oxygen therapy or pao2/fio2<300mmhg - dd>1000µg/l - pcr >150mg/l - il6 >40pg/ml 3. age > 18 years 4. weight 50-100 kg 5. after receiving oral and written information about the study, patient must give informed consent duly signed and dated before performing any activity related to the study.

inclusion criteria: 1. patients admitted to hospital with covid-19, pcr + sars-cov-2 infection or (presence of infiltrate compatible with chest x-ray or tc) 2. patients with, at least, one of the following evolution disease risk criteria: - sat 02<94% - need for oxygen therapy or pao2/fio2<300mmhg - dd>1000µg/l - pcr >150mg/l - il6 >40pg/ml 3. age > 18 years 4. weight 50-100 kg 5. after receiving oral and written information about the study, patient must give informed consent duly signed and dated before performing any activity related to the study.