inclusion criteria: * provides informed consent * has laboratory-confirmed sars-cov-2 infection as determined by polymerase chain reaction (pcr) or other commercial or public health assay in any specimen * 3. is hospitalized with covid-19-induced ard or ards (any severity) with a pao2/fio2 ≤300. the pao2/fio2 may be estimated from pulse oximetry or determined by arterial blood gas * requires oxygen supplementation at screening * is willing to follow contraception requirements

inclusion criteria: * provides informed consent * has laboratory-confirmed sars-cov-2 infection as determined by polymerase chain reaction (pcr) or other commercial or public health assay in any specimen * 3. is hospitalized with covid-19-induced ard or ards (any severity) with a pao2/fio2 ≤300. the pao2/fio2 may be estimated from pulse oximetry or determined by arterial blood gas * requires oxygen supplementation at screening * is willing to follow contraception requirements

inclusion criteria: - provides informed consent - has laboratory-confirmed sars-cov-2 infection as determined by polymerase chain reaction (pcr) or other commercial or public health assay in any specimen - 3. is hospitalized with covid-19-induced ard or ards (any severity) with a pao2/fio2 ≤300. the pao2/fio2 may be estimated from pulse oximetry or determined by arterial blood gas - requires oxygen supplementation at screening - is willing to follow contraception requirements

inclusion criteria: - provides informed consent - has laboratory-confirmed sars-cov-2 infection as determined by polymerase chain reaction (pcr) or other commercial or public health assay in any specimen - 3. is hospitalized with covid-19-induced ard or ards (any severity) with a pao2/fio2 ≤300. the pao2/fio2 may be estimated from pulse oximetry or determined by arterial blood gas - requires oxygen supplementation at screening - is willing to follow contraception requirements