inclusion criteria: * age ≥ 18 years old * adult patients with positive rt-pcr test for sars-cov2 (nasal swabs or lower respiratory tract sample), diagnosed with pneumonia (\<= 10 days) according to the following definitions: * suggestive radiological imaging (ct, rx, ultrasound); * respiratory failure not fully explained by heart failure or fluid overload; * pao2/fio2 200-350 mmhg; * signed informed consent

inclusion criteria: * age ≥ 18 years old * adult patients with positive rt-pcr test for sars-cov2 (nasal swabs or lower respiratory tract sample), diagnosed with pneumonia (\<= 10 days) according to the following definitions: * suggestive radiological imaging (ct, rx, ultrasound); * respiratory failure not fully explained by heart failure or fluid overload; * pao2/fio2 200-350 mmhg; * signed informed consent

inclusion criteria: - age ≥ 18 years old - adult patients with positive rt-pcr test for sars-cov2 (nasal swabs or lower respiratory tract sample), diagnosed with pneumonia (<= 10 days) according to the following definitions: - suggestive radiological imaging (ct, rx, ultrasound); - respiratory failure not fully explained by heart failure or fluid overload; - pao2/fio2 200-350 mmhg; - signed informed consent

inclusion criteria: - age ≥ 18 years old - adult patients with positive rt-pcr test for sars-cov2 (nasal swabs or lower respiratory tract sample), diagnosed with pneumonia (<= 10 days) according to the following definitions: - suggestive radiological imaging (ct, rx, ultrasound); - respiratory failure not fully explained by heart failure or fluid overload; - pao2/fio2 200-350 mmhg; - signed informed consent