* need of non invasive or invasive mechanical ventilation at the time of randomization; * pao2/fio2 \<200; * patients with hypersensitivity or allergic reaction to blood products or immunoglobulins; * patients who expressly refuse to adhere the clinical study; * use of il-6 receptor inhibitors, il-1 inhibitors, jak inhibitors, tnf inhibitors; * patients participating to other clinical trial.

* need of non invasive or invasive mechanical ventilation at the time of randomization; * pao2/fio2 \<200; * patients with hypersensitivity or allergic reaction to blood products or immunoglobulins; * patients who expressly refuse to adhere the clinical study; * use of il-6 receptor inhibitors, il-1 inhibitors, jak inhibitors, tnf inhibitors; * patients participating to other clinical trial.

- need of non invasive or invasive mechanical ventilation at the time of randomization; - pao2/fio2 <200; - patients with hypersensitivity or allergic reaction to blood products or immunoglobulins; - patients who expressly refuse to adhere the clinical study; - use of il-6 receptor inhibitors, il-1 inhibitors, jak inhibitors, tnf inhibitors; - patients participating to other clinical trial.

- need of non invasive or invasive mechanical ventilation at the time of randomization; - pao2/fio2 <200; - patients with hypersensitivity or allergic reaction to blood products or immunoglobulins; - patients who expressly refuse to adhere the clinical study; - use of il-6 receptor inhibitors, il-1 inhibitors, jak inhibitors, tnf inhibitors; - patients participating to other clinical trial.