inclusion criteria: * aged 18-90 male or female * laboratory approve of rt-pcr (real-time reverse transcription polymerase chain reaction) with covid-19 infection * pneumonia assessed by chest radiography or computed tomography * in accordance with any of the following: 1)respiratory rate ≥ 30 times / min 2) oxygen saturation ≤ 93% 3) arterial pressure of oxygen/the fraction of inspired oxygen≤ 300mmhg, 4) pulmonary imaging of focus within 24-48 hours \> 50% progression * patients who remain unresponsive to medications administered according to ministry of health guidelines * patients who receiving invasive or non-invasive mechanical ventilation therapy in intensive care

inclusion criteria: * aged 18-90 male or female * laboratory approve of rt-pcr (real-time reverse transcription polymerase chain reaction) with covid-19 infection * pneumonia assessed by chest radiography or computed tomography * in accordance with any of the following: 1)respiratory rate ≥ 30 times / min 2) oxygen saturation ≤ 93% 3) arterial pressure of oxygen/the fraction of inspired oxygen≤ 300mmhg, 4) pulmonary imaging of focus within 24-48 hours \> 50% progression * patients who remain unresponsive to medications administered according to ministry of health guidelines * patients who receiving invasive or non-invasive mechanical ventilation therapy in intensive care

inclusion criteria: - aged 18-90 male or female - laboratory approve of rt-pcr (real-time reverse transcription polymerase chain reaction) with covid-19 infection - pneumonia assessed by chest radiography or computed tomography - in accordance with any of the following: 1)respiratory rate ≥ 30 times / min 2) oxygen saturation ≤ 93% 3) arterial pressure of oxygen/the fraction of inspired oxygen≤ 300mmhg, 4) pulmonary imaging of focus within 24-48 hours > 50% progression - patients who remain unresponsive to medications administered according to ministry of health guidelines - patients who receiving invasive or non-invasive mechanical ventilation therapy in intensive care

inclusion criteria: - aged 18-90 male or female - laboratory approve of rt-pcr (real-time reverse transcription polymerase chain reaction) with covid-19 infection - pneumonia assessed by chest radiography or computed tomography - in accordance with any of the following: 1)respiratory rate ≥ 30 times / min 2) oxygen saturation ≤ 93% 3) arterial pressure of oxygen/the fraction of inspired oxygen≤ 300mmhg, 4) pulmonary imaging of focus within 24-48 hours > 50% progression - patients who remain unresponsive to medications administered according to ministry of health guidelines - patients who receiving invasive or non-invasive mechanical ventilation therapy in intensive care