inclusion criteria: 1. male or female subject aged ≥18 years. 2. estimated bmi ≥19kg/m² to ≤40kg/m². 3. florid1 sars-cov-2 infection confirmed by rt-pcr in tracheo-bronchial secretion sample or pharyngeal swab sample. 4. ards with horovitz index \<300mmhg. 5. necessity of invasive mechanical ventilation. 6. written informed consent obtained from the subject's legal representative or under such arrangement as is legally acceptable in germany ( 7. subject's assent if obtainable

inclusion criteria: 1. male or female subject aged ≥18 years. 2. estimated bmi ≥19kg/m² to ≤40kg/m². 3. florid1 sars-cov-2 infection confirmed by rt-pcr in tracheo-bronchial secretion sample or pharyngeal swab sample. 4. ards with horovitz index \<300mmhg. 5. necessity of invasive mechanical ventilation. 6. written informed consent obtained from the subject's legal representative or under such arrangement as is legally acceptable in germany ( 7. subject's assent if obtainable

inclusion criteria: male or female subject aged ≥18 years. estimated bmi ≥19kg/m² to ≤40kg/m². florid1 sars-cov-2 infection confirmed by rt-pcr in tracheo-bronchial secretion sample or pharyngeal swab sample. ards with horovitz index <300mmhg. necessity of invasive mechanical ventilation. written informed consent obtained from the subject's legal representative or under such arrangement as is legally acceptable in germany ( subject's assent if obtainable

inclusion criteria: male or female subject aged ≥18 years. estimated bmi ≥19kg/m² to ≤40kg/m². florid1 sars-cov-2 infection confirmed by rt-pcr in tracheo-bronchial secretion sample or pharyngeal swab sample. ards with horovitz index <300mmhg. necessity of invasive mechanical ventilation. written informed consent obtained from the subject's legal representative or under such arrangement as is legally acceptable in germany ( subject's assent if obtainable

inclusion criteria: 1. male or female subject aged ≥18 years. 2. estimated bmi ≥19kg/m² to ≤40kg/m². 3. florid1 sars-cov-2 infection confirmed by rt-pcr in tracheo-bronchial secretion sample or pharyngeal swab sample. 4. ards with horovitz index <300mmhg. 5. necessity of invasive mechanical ventilation. 6. written informed consent obtained from the subject's legal representative or under such arrangement as is legally acceptable in germany ( 7. subject's assent if obtainable

inclusion criteria: 1. male or female subject aged ≥18 years. 2. estimated bmi ≥19kg/m² to ≤40kg/m². 3. florid1 sars-cov-2 infection confirmed by rt-pcr in tracheo-bronchial secretion sample or pharyngeal swab sample. 4. ards with horovitz index <300mmhg. 5. necessity of invasive mechanical ventilation. 6. written informed consent obtained from the subject's legal representative or under such arrangement as is legally acceptable in germany ( 7. subject's assent if obtainable