inclusion criteria: - must agree to use two methods of birth control from screening through 90 days after administration of the last dose of study drug - females must have a negative pregnancy test at screening and prior to dosing - minimum body weight of 50 kg and body mass index (bmi) of 18-32 kg/m2 - willing to comply with the study requirements and to provide written informed consent

inclusion criteria: - must agree to use two methods of birth control from screening through 90 days after administration of the last dose of study drug - females must have a negative pregnancy test at screening and prior to dosing - minimum body weight of 50 kg and body mass index (bmi) of 18-32 kg/m2 - willing to comply with the study requirements and to provide written informed consent