* active heart disease or active cancer at time of recruitment; * patients in intensive care unit at the time of recruitment; * patents with alanine transaminase and aspartate transaminase greater than 5 times the upper limit of normal at any time; * patients requiring \>4l per minute of oxygen support at the time of recruitment.

* active heart disease or active cancer at time of recruitment; * patients in intensive care unit at the time of recruitment; * patents with alanine transaminase and aspartate transaminase greater than 5 times the upper limit of normal at any time; * patients requiring \>4l per minute of oxygen support at the time of recruitment.

- active heart disease or active cancer at time of recruitment; - patients in intensive care unit at the time of recruitment; - patents with alanine transaminase and aspartate transaminase greater than 5 times the upper limit of normal at any time; - patients requiring >4l per minute of oxygen support at the time of recruitment.

- active heart disease or active cancer at time of recruitment; - patients in intensive care unit at the time of recruitment; - patents with alanine transaminase and aspartate transaminase greater than 5 times the upper limit of normal at any time; - patients requiring >4l per minute of oxygen support at the time of recruitment.