aggravated allergic history, drug intolerance, including hypersensitivity to any of the components of the study drug, as well as a history of serious adverse events during vaccine administration (such as allergic reactions, respiratory failure, angioedema, abdominal pain). acute illness with a fever (body temperature ≥37.1 ° c) at the time of screening. history of chronic alcohol abuse and/or drug use. positive results for antibodies igm, igg to sars-cov-2 women with a positive urine pregnancy test. simultaneous treatment with immunosuppressive drugs, incl. corticosteroids (2 weeks) 4 weeks prior to study drug administration. acute or chronic clinically significant lesions of the lungs, cardiovascular system, gastrointestinal tract, liver, blood system, skin, endocrine, neurological and psychiatric diseases or impaired renal function (asthma, diabetes, thyroid disease, arrhythmia, heart attack myocardium, severe hypertension not controlled by drugs, etc.), identified based on the data of the medical history, physical examination, which, according to the researcher, may affect the study result. history of platelet disorder or other blood clotting disorders that may cause contraindications to intramuscular administration. history of leukemia or neoplasm. persons with autoimmune diseases. a history of guillain-barré syndrome or other neuroimmunological diseases. subjects who received antiviral drugs, immunoglobulins or blood transfusions or any other investigational drug within 4 weeks prior to study drug administration; subjects who received anti-inflammatory drugs 2 days prior to study drug administration; participation in any other clinical research within the last 6 months. subjects with regard to whom there is a concern that they will not comply with the requirements of the study, or persons with severe physical or mental disabilities that may affect the completion of the study. voluntary refusal to study. vulnerable research subjects.

aggravated allergic history, drug intolerance, including hypersensitivity to any of the components of the study drug, as well as a history of serious adverse events during vaccine administration (such as allergic reactions, respiratory failure, angioedema, abdominal pain). acute illness with a fever (body temperature ≥37.1 ° c) at the time of screening. history of chronic alcohol abuse and/or drug use. positive results for antibodies igm, igg to sars-cov-2 women with a positive urine pregnancy test. simultaneous treatment with immunosuppressive drugs, incl. corticosteroids (2 weeks) 4 weeks prior to study drug administration. acute or chronic clinically significant lesions of the lungs, cardiovascular system, gastrointestinal tract, liver, blood system, skin, endocrine, neurological and psychiatric diseases or impaired renal function (asthma, diabetes, thyroid disease, arrhythmia, heart attack myocardium, severe hypertension not controlled by drugs, etc.), identified based on the data of the medical history, physical examination, which, according to the researcher, may affect the study result. history of platelet disorder or other blood clotting disorders that may cause contraindications to intramuscular administration. history of leukemia or neoplasm. persons with autoimmune diseases. a history of guillain-barré syndrome or other neuroimmunological diseases. subjects who received antiviral drugs, immunoglobulins or blood transfusions or any other investigational drug within 4 weeks prior to study drug administration; subjects who received anti-inflammatory drugs 2 days prior to study drug administration; participation in any other clinical research within the last 6 months. subjects with regard to whom there is a concern that they will not comply with the requirements of the study, or persons with severe physical or mental disabilities that may affect the completion of the study. voluntary refusal to study. vulnerable research subjects.