inclusion criteria: * judged to be healthy by the investigator on the basis of medical history, physical examination and vital signs performed at screening. * able and willing to comply with all study procedures. * screening laboratory results within normal limits or deemed not clinically significant by the investigator. * body mass index of 18-30 kg/m\^2, inclusive, at screening. * negative serological tests for hepatitis b surface antigen (hbsag), hepatitis c antibody and human immunodeficiency virus (hiv) antibody at screening. * screening electrocardiogram (ecg) deemed by the investigator as having no clinically significant findings (e.g. wolff-parkinson-white syndrome). * use of medically effective contraception with a failure rate of \< 1% per year when used consistently and correctly from screening until 3 months following last dose, be post-menopausal, be surgically sterile or have a partner who is sterile.

inclusion criteria: * judged to be healthy by the investigator on the basis of medical history, physical examination and vital signs performed at screening. * able and willing to comply with all study procedures. * screening laboratory results within normal limits or deemed not clinically significant by the investigator. * body mass index of 18-30 kg/m\^2, inclusive, at screening. * negative serological tests for hepatitis b surface antigen (hbsag), hepatitis c antibody and human immunodeficiency virus (hiv) antibody at screening. * screening electrocardiogram (ecg) deemed by the investigator as having no clinically significant findings (e.g. wolff-parkinson-white syndrome). * use of medically effective contraception with a failure rate of \< 1% per year when used consistently and correctly from screening until 3 months following last dose, be post-menopausal, be surgically sterile or have a partner who is sterile.

inclusion criteria: - judged to be healthy by the investigator on the basis of medical history, physical examination and vital signs performed at screening. - able and willing to comply with all study procedures. - screening laboratory results within normal limits or deemed not clinically significant by the investigator. - body mass index of 18-30 kg/m^2, inclusive, at screening. - negative serological tests for hepatitis b surface antigen (hbsag), hepatitis c antibody and human immunodeficiency virus (hiv) antibody at screening. - screening electrocardiogram (ecg) deemed by the investigator as having no clinically significant findings (e.g. wolff-parkinson-white syndrome). - use of medically effective contraception with a failure rate of < 1% per year when used consistently and correctly from screening until 3 months following last dose, be post-menopausal, be surgically sterile or have a partner who is sterile.

inclusion criteria: - judged to be healthy by the investigator on the basis of medical history, physical examination and vital signs performed at screening. - able and willing to comply with all study procedures. - screening laboratory results within normal limits or deemed not clinically significant by the investigator. - body mass index of 18-30 kg/m^2, inclusive, at screening. - negative serological tests for hepatitis b surface antigen (hbsag), hepatitis c antibody and human immunodeficiency virus (hiv) antibody at screening. - screening electrocardiogram (ecg) deemed by the investigator as having no clinically significant findings (e.g. wolff-parkinson-white syndrome). - use of medically effective contraception with a failure rate of < 1% per year when used consistently and correctly from screening until 3 months following last dose, be post-menopausal, be surgically sterile or have a partner who is sterile.