inclusion criteria: 1. age = 18 years; 2. informed consent for participation in the study and for data processing; 3. molecular diagnosis with polymerase chain reaction (pcr) test of sars-cov2 infection; 4. hospitalization in a specialist ward for covid-19 patient care (eg., infectious diseases, pulmonology or internal medicine); 5. need for supplemental oxygen in any delivery mode with the exception of invasive mechanical ventilation; 6. pao2 / fio2 between 100 and 300 mmhg. 7. clinical / instrumental diagnosis (high resolution chest ct scan or chest x-ray or lung ultrasound) of interstitial pneumonia for no more than three days; 8. serum crp greater than 5 mg / dl; 9. interval from onset of sars-cov2 infection symptoms to randomization\> 5 days-

inclusion criteria: 1. age = 18 years; 2. informed consent for participation in the study and for data processing; 3. molecular diagnosis with polymerase chain reaction (pcr) test of sars-cov2 infection; 4. hospitalization in a specialist ward for covid-19 patient care (eg., infectious diseases, pulmonology or internal medicine); 5. need for supplemental oxygen in any delivery mode with the exception of invasive mechanical ventilation; 6. pao2 / fio2 between 100 and 300 mmhg. 7. clinical / instrumental diagnosis (high resolution chest ct scan or chest x-ray or lung ultrasound) of interstitial pneumonia for no more than three days; 8. serum crp greater than 5 mg / dl; 9. interval from onset of sars-cov2 infection symptoms to randomization\> 5 days-

inclusion criteria: age = 18 years; informed consent for participation in the study and for data processing; molecular diagnosis with polymerase chain reaction (pcr) test of sars-cov2 infection; hospitalization in a specialist ward for covid-19 patient care (eg., infectious diseases, pulmonology or internal medicine); need for supplemental oxygen in any delivery mode with the exception of invasive mechanical ventilation; pao2 / fio2 between 100 and 300 mmhg. clinical / instrumental diagnosis (high resolution chest ct scan or chest x-ray or lung ultrasound) of interstitial pneumonia for no more than three days; serum crp greater than 5 mg / dl; interval from onset of sars-cov2 infection symptoms to randomization> 5 days-

inclusion criteria: age = 18 years; informed consent for participation in the study and for data processing; molecular diagnosis with polymerase chain reaction (pcr) test of sars-cov2 infection; hospitalization in a specialist ward for covid-19 patient care (eg., infectious diseases, pulmonology or internal medicine); need for supplemental oxygen in any delivery mode with the exception of invasive mechanical ventilation; pao2 / fio2 between 100 and 300 mmhg. clinical / instrumental diagnosis (high resolution chest ct scan or chest x-ray or lung ultrasound) of interstitial pneumonia for no more than three days; serum crp greater than 5 mg / dl; interval from onset of sars-cov2 infection symptoms to randomization> 5 days-

inclusion criteria: 1. age = 18 years; 2. informed consent for participation in the study and for data processing; 3. molecular diagnosis with polymerase chain reaction (pcr) test of sars-cov2 infection; 4. hospitalization in a specialist ward for covid-19 patient care (eg., infectious diseases, pulmonology or internal medicine); 5. need for supplemental oxygen in any delivery mode with the exception of invasive mechanical ventilation; 6. pao2 / fio2 between 100 and 300 mmhg. 7. clinical / instrumental diagnosis (high resolution chest ct scan or chest x-ray or lung ultrasound) of interstitial pneumonia for no more than three days; 8. serum crp greater than 5 mg / dl; 9. interval from onset of sars-cov2 infection symptoms to randomization> 5 days-

inclusion criteria: 1. age = 18 years; 2. informed consent for participation in the study and for data processing; 3. molecular diagnosis with polymerase chain reaction (pcr) test of sars-cov2 infection; 4. hospitalization in a specialist ward for covid-19 patient care (eg., infectious diseases, pulmonology or internal medicine); 5. need for supplemental oxygen in any delivery mode with the exception of invasive mechanical ventilation; 6. pao2 / fio2 between 100 and 300 mmhg. 7. clinical / instrumental diagnosis (high resolution chest ct scan or chest x-ray or lung ultrasound) of interstitial pneumonia for no more than three days; 8. serum crp greater than 5 mg / dl; 9. interval from onset of sars-cov2 infection symptoms to randomization> 5 days-