individuals who: 1. have had sars-cov-2 infection or covid-19 disease. 2. have had cancer except for cancers that were treated and that have low risk of returning 3. have chronic kidney disease 4. have some chronic lung diseases 5. have some heart conditions 6. have compromised immune systems 7. are obese 8. have sickle cell disease or some other blood disorders 9. are current smokers and/or use illegal drugs 10. have type 2 diabetics 11. are immunocompromised, immunodeficient or have had a transplant 12. have autoimmune disease 13. have other severe or uncontrolled diseases or disease that may interfere with the interpretation of the study 14. have a positive test for hepatitis b or c or human immunodeficiency virus 15. have had a severe reaction to previous investigational vaccines 16. have a fever or are feeling sick close to the time of the first vaccination of the study 17. have positive drug test at screening 18. are pregnant 19. are breastfeeding 20. have a bleeding disorder 21. have previously received an investigational coronavirus vaccine (sars-cov(1) or mers) or who plan to be in other covid-19 studies 22. have recently been vaccinated with other vaccines 23. have recently received blood products 24. who work at one of the clinic sites participating in this study, work at arcturus, who work at other companies that monitor the study or close family members to the sites, arcturus, or partners involved in study monitoring 25. other restrictions may apply

individuals who: 1. have had sars-cov-2 infection or covid-19 disease. 2. have had cancer except for cancers that were treated and that have low risk of returning 3. have chronic kidney disease 4. have some chronic lung diseases 5. have some heart conditions 6. have compromised immune systems 7. are obese 8. have sickle cell disease or some other blood disorders 9. are current smokers and/or use illegal drugs 10. have type 2 diabetics 11. are immunocompromised, immunodeficient or have had a transplant 12. have autoimmune disease 13. have other severe or uncontrolled diseases or disease that may interfere with the interpretation of the study 14. have a positive test for hepatitis b or c or human immunodeficiency virus 15. have had a severe reaction to previous investigational vaccines 16. have a fever or are feeling sick close to the time of the first vaccination of the study 17. have positive drug test at screening 18. are pregnant 19. are breastfeeding 20. have a bleeding disorder 21. have previously received an investigational coronavirus vaccine (sars-cov(1) or mers) or who plan to be in other covid-19 studies 22. have recently been vaccinated with other vaccines 23. have recently received blood products 24. who work at one of the clinic sites participating in this study, work at arcturus, who work at other companies that monitor the study or close family members to the sites, arcturus, or partners involved in study monitoring 25. other restrictions may apply

individuals who: have had sars-cov-2 infection or covid-19 disease. have had cancer except for cancers that were treated and that have low risk of returning have chronic kidney disease have some chronic lung diseases have some heart conditions have compromised immune systems are obese have sickle cell disease or some other blood disorders are current smokers and/or use illegal drugs have type 2 diabetics are immunocompromised, immunodeficient or have had a transplant have autoimmune disease have other severe or uncontrolled diseases or disease that may interfere with the interpretation of the study have a positive test for hepatitis b or c or human immunodeficiency virus have had a severe reaction to previous investigational vaccines have a fever or are feeling sick close to the time of the first vaccination of the study have positive drug test at screening are pregnant are breastfeeding have a bleeding disorder have previously received an investigational coronavirus vaccine (sars-cov(1) or mers) or who plan to be in other covid-19 studies have recently been vaccinated with other vaccines have recently received blood products who work at one of the clinic sites participating in this study, work at arcturus, who work at other companies that monitor the study or close family members to the sites, arcturus, or partners involved in study monitoring other restrictions may apply

individuals who: have had sars-cov-2 infection or covid-19 disease. have had cancer except for cancers that were treated and that have low risk of returning have chronic kidney disease have some chronic lung diseases have some heart conditions have compromised immune systems are obese have sickle cell disease or some other blood disorders are current smokers and/or use illegal drugs have type 2 diabetics are immunocompromised, immunodeficient or have had a transplant have autoimmune disease have other severe or uncontrolled diseases or disease that may interfere with the interpretation of the study have a positive test for hepatitis b or c or human immunodeficiency virus have had a severe reaction to previous investigational vaccines have a fever or are feeling sick close to the time of the first vaccination of the study have positive drug test at screening are pregnant are breastfeeding have a bleeding disorder have previously received an investigational coronavirus vaccine (sars-cov(1) or mers) or who plan to be in other covid-19 studies have recently been vaccinated with other vaccines have recently received blood products who work at one of the clinic sites participating in this study, work at arcturus, who work at other companies that monitor the study or close family members to the sites, arcturus, or partners involved in study monitoring other restrictions may apply

individuals who: 1. have had sars-cov-2 infection or covid-19 disease. 2. have had cancer except for cancers that were treated and that have low risk of returning 3. have chronic kidney disease 4. have some chronic lung diseases 5. have some heart conditions 6. have compromised immune systems 7. are obese 8. have sickle cell disease or some other blood disorders 9. are current smokers and/or use illegal drugs 10. have type 2 diabetics 11. are immunocompromised, immunodeficient or have had a transplant 12. have autoimmune disease 13. have other severe or uncontrolled diseases or disease that may interfere with the interpretation of the study 14. have a positive test for hepatitis b or c or human immunodeficiency virus 15. have had a severe reaction to previous investigational vaccines 16. have a fever or are feeling sick close to the time of the first vaccination of the study 17. have positive drug test at screening 18. are pregnant 19. are breastfeeding 20. have a bleeding disorder 21. have previously received an investigational coronavirus vaccine (sars-cov(1) or mers) or who plan to be in other covid-19 studies 22. have recently been vaccinated with other vaccines 23. have recently received blood products 24. who work at one of the clinic sites participating in this study, work at arcturus, who work at other companies that monitor the study or close family members to the sites, arcturus, or partners involved in study monitoring 25. other restrictions may apply

individuals who: 1. have had sars-cov-2 infection or covid-19 disease. 2. have had cancer except for cancers that were treated and that have low risk of returning 3. have chronic kidney disease 4. have some chronic lung diseases 5. have some heart conditions 6. have compromised immune systems 7. are obese 8. have sickle cell disease or some other blood disorders 9. are current smokers and/or use illegal drugs 10. have type 2 diabetics 11. are immunocompromised, immunodeficient or have had a transplant 12. have autoimmune disease 13. have other severe or uncontrolled diseases or disease that may interfere with the interpretation of the study 14. have a positive test for hepatitis b or c or human immunodeficiency virus 15. have had a severe reaction to previous investigational vaccines 16. have a fever or are feeling sick close to the time of the first vaccination of the study 17. have positive drug test at screening 18. are pregnant 19. are breastfeeding 20. have a bleeding disorder 21. have previously received an investigational coronavirus vaccine (sars-cov(1) or mers) or who plan to be in other covid-19 studies 22. have recently been vaccinated with other vaccines 23. have recently received blood products 24. who work at one of the clinic sites participating in this study, work at arcturus, who work at other companies that monitor the study or close family members to the sites, arcturus, or partners involved in study monitoring 25. other restrictions may apply