1. patient showing signs of respiratory failure necessitating mechanical ventilation 2. pregnant or nursing women. note: women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation. should a man father a child, or a woman become pregnant or suspect she is pregnant while participating in this study, he or she should inform the treating physician immediately. 3. active or uncontrolled infections other than covid-19 or with serious illnesses or medical conditions which would not permit the patient to receive study treatment 4. active or planned concomitant treatment with other investigational antivirals or immunomodulators 5. chronic diarrhea (excess of 2-3 stools/day above normal frequency) 6. current use or anticipated need for drugs that are known strong inhibitors or inducers of major cyp enzymes.

1. patient showing signs of respiratory failure necessitating mechanical ventilation 2. pregnant or nursing women. note: women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation. should a man father a child, or a woman become pregnant or suspect she is pregnant while participating in this study, he or she should inform the treating physician immediately. 3. active or uncontrolled infections other than covid-19 or with serious illnesses or medical conditions which would not permit the patient to receive study treatment 4. active or planned concomitant treatment with other investigational antivirals or immunomodulators 5. chronic diarrhea (excess of 2-3 stools/day above normal frequency) 6. current use or anticipated need for drugs that are known strong inhibitors or inducers of major cyp enzymes.

patient showing signs of respiratory failure necessitating mechanical ventilation pregnant or nursing women. note: women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation. should a man father a child, or a woman become pregnant or suspect she is pregnant while participating in this study, he or she should inform the treating physician immediately. active or uncontrolled infections other than covid-19 or with serious illnesses or medical conditions which would not permit the patient to receive study treatment active or planned concomitant treatment with other investigational antivirals or immunomodulators chronic diarrhea (excess of 2-3 stools/day above normal frequency) current use or anticipated need for drugs that are known strong inhibitors or inducers of major cyp enzymes.

patient showing signs of respiratory failure necessitating mechanical ventilation pregnant or nursing women. note: women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation. should a man father a child, or a woman become pregnant or suspect she is pregnant while participating in this study, he or she should inform the treating physician immediately. active or uncontrolled infections other than covid-19 or with serious illnesses or medical conditions which would not permit the patient to receive study treatment active or planned concomitant treatment with other investigational antivirals or immunomodulators chronic diarrhea (excess of 2-3 stools/day above normal frequency) current use or anticipated need for drugs that are known strong inhibitors or inducers of major cyp enzymes.

1. patient showing signs of respiratory failure necessitating mechanical ventilation 2. pregnant or nursing women. note: women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation. should a man father a child, or a woman become pregnant or suspect she is pregnant while participating in this study, he or she should inform the treating physician immediately. 3. active or uncontrolled infections other than covid-19 or with serious illnesses or medical conditions which would not permit the patient to receive study treatment 4. active or planned concomitant treatment with other investigational antivirals or immunomodulators 5. chronic diarrhea (excess of 2-3 stools/day above normal frequency) 6. current use or anticipated need for drugs that are known strong inhibitors or inducers of major cyp enzymes.

1. patient showing signs of respiratory failure necessitating mechanical ventilation 2. pregnant or nursing women. note: women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation. should a man father a child, or a woman become pregnant or suspect she is pregnant while participating in this study, he or she should inform the treating physician immediately. 3. active or uncontrolled infections other than covid-19 or with serious illnesses or medical conditions which would not permit the patient to receive study treatment 4. active or planned concomitant treatment with other investigational antivirals or immunomodulators 5. chronic diarrhea (excess of 2-3 stools/day above normal frequency) 6. current use or anticipated need for drugs that are known strong inhibitors or inducers of major cyp enzymes.