inclusion criteria: 1. able and willing to agree informed consent and aged 19 to 64 years. 2. the bmi index is 18.5 kg/m2 to 30.0 kg/m2. 3. weigh 40kg to 100kg (part a only) 4. able and willing to medically effective contraception during the whole study period. 5. agreement to refrain from blood donation during the whole study period.

inclusion criteria: 1. able and willing to agree informed consent and aged 19 to 64 years. 2. the bmi index is 18.5 kg/m2 to 30.0 kg/m2. 3. weigh 40kg to 100kg (part a only) 4. able and willing to medically effective contraception during the whole study period. 5. agreement to refrain from blood donation during the whole study period.

inclusion criteria: able and willing to agree informed consent and aged 19 to 64 years. the bmi index is 18.5 kg/m2 to 30.0 kg/m2. weigh 40kg to 100kg (part a only) able and willing to medically effective contraception during the whole study period. agreement to refrain from blood donation during the whole study period.

inclusion criteria: able and willing to agree informed consent and aged 19 to 64 years. the bmi index is 18.5 kg/m2 to 30.0 kg/m2. weigh 40kg to 100kg (part a only) able and willing to medically effective contraception during the whole study period. agreement to refrain from blood donation during the whole study period.

inclusion criteria: 1. able and willing to agree informed consent and aged 19 to 64 years. 2. the bmi index is 18.5 kg/m2 to 30.0 kg/m2. 3. weigh 40kg to 100kg (part a only) 4. able and willing to medically effective contraception during the whole study period. 5. agreement to refrain from blood donation during the whole study period.

inclusion criteria: 1. able and willing to agree informed consent and aged 19 to 64 years. 2. the bmi index is 18.5 kg/m2 to 30.0 kg/m2. 3. weigh 40kg to 100kg (part a only) 4. able and willing to medically effective contraception during the whole study period. 5. agreement to refrain from blood donation during the whole study period.