inclusion criteria: 1. agree to sign the study informed consent form (icf) before performing any study-specific procedure. 2. adults, i.e., ≥ 18 years old. 3. negative hiv, hepatitis b, hepatitis c, and syphilis test results 4. negative igm and igg sars cov2 antibodies enzyme immunoassay test result. 5. negative covid-19 rt-pcr test result at the screening visit. 6. no covid-19 in medical history. 7. subjects to confirm they had no contact with covid-19 persons within at least 14 days before the screening visit. 8. consent for using effective methods of contraception during the entire trial1 9. a negative urine pregnancy test at the screening visit (for child-bearing age women). 10. negative alcohol test at the screening visit. 11. no evidence of vaccine-induced reactions or complications after receiving immunobiological products in medical history. 12. no acute infectious and/or respiratory diseases within at least 14 days before the enrollment.

inclusion criteria: 1. agree to sign the study informed consent form (icf) before performing any study-specific procedure. 2. adults, i.e., ≥ 18 years old. 3. negative hiv, hepatitis b, hepatitis c, and syphilis test results 4. negative igm and igg sars cov2 antibodies enzyme immunoassay test result. 5. negative covid-19 rt-pcr test result at the screening visit. 6. no covid-19 in medical history. 7. subjects to confirm they had no contact with covid-19 persons within at least 14 days before the screening visit. 8. consent for using effective methods of contraception during the entire trial1 9. a negative urine pregnancy test at the screening visit (for child-bearing age women). 10. negative alcohol test at the screening visit. 11. no evidence of vaccine-induced reactions or complications after receiving immunobiological products in medical history. 12. no acute infectious and/or respiratory diseases within at least 14 days before the enrollment.

inclusion criteria: agree to sign the study informed consent form (icf) before performing any study-specific procedure. adults, i.e., ≥ 18 years old. negative hiv, hepatitis b, hepatitis c, and syphilis test results negative igm and igg sars cov2 antibodies enzyme immunoassay test result. negative covid-19 rt-pcr test result at the screening visit. no covid-19 in medical history. subjects to confirm they had no contact with covid-19 persons within at least 14 days before the screening visit. consent for using effective methods of contraception during the entire trial1 a negative urine pregnancy test at the screening visit (for child-bearing age women). negative alcohol test at the screening visit. no evidence of vaccine-induced reactions or complications after receiving immunobiological products in medical history. no acute infectious and/or respiratory diseases within at least 14 days before the enrollment.

inclusion criteria: agree to sign the study informed consent form (icf) before performing any study-specific procedure. adults, i.e., ≥ 18 years old. negative hiv, hepatitis b, hepatitis c, and syphilis test results negative igm and igg sars cov2 antibodies enzyme immunoassay test result. negative covid-19 rt-pcr test result at the screening visit. no covid-19 in medical history. subjects to confirm they had no contact with covid-19 persons within at least 14 days before the screening visit. consent for using effective methods of contraception during the entire trial1 a negative urine pregnancy test at the screening visit (for child-bearing age women). negative alcohol test at the screening visit. no evidence of vaccine-induced reactions or complications after receiving immunobiological products in medical history. no acute infectious and/or respiratory diseases within at least 14 days before the enrollment.

inclusion criteria: 1. agree to sign the study informed consent form (icf) before performing any study-specific procedure. 2. adults, i.e., ≥ 18 years old. 3. negative hiv, hepatitis b, hepatitis c, and syphilis test results 4. negative igm and igg sars cov2 antibodies enzyme immunoassay test result. 5. negative covid-19 rt-pcr test result at the screening visit. 6. no covid-19 in medical history. 7. subjects to confirm they had no contact with covid-19 persons within at least 14 days before the screening visit. 8. consent for using effective methods of contraception during the entire trial1 9. a negative urine pregnancy test at the screening visit (for child-bearing age women). 10. negative alcohol test at the screening visit. 11. no evidence of vaccine-induced reactions or complications after receiving immunobiological products in medical history. 12. no acute infectious and/or respiratory diseases within at least 14 days before the enrollment.

inclusion criteria: 1. agree to sign the study informed consent form (icf) before performing any study-specific procedure. 2. adults, i.e., ≥ 18 years old. 3. negative hiv, hepatitis b, hepatitis c, and syphilis test results 4. negative igm and igg sars cov2 antibodies enzyme immunoassay test result. 5. negative covid-19 rt-pcr test result at the screening visit. 6. no covid-19 in medical history. 7. subjects to confirm they had no contact with covid-19 persons within at least 14 days before the screening visit. 8. consent for using effective methods of contraception during the entire trial1 9. a negative urine pregnancy test at the screening visit (for child-bearing age women). 10. negative alcohol test at the screening visit. 11. no evidence of vaccine-induced reactions or complications after receiving immunobiological products in medical history. 12. no acute infectious and/or respiratory diseases within at least 14 days before the enrollment.