inclusion criteria: * men and women between the ages 18-80 years * diagnosis of covid19 with severe ards (pao2/fio2 \<150mmhg) * admission to the icu and in need of mechanical ventilation * able to give informed consent according to local regulations. if the patient is unable to give written informed consent, the form will be read to them and their verbal consent will be documented. if the patient is sedated, an impartial icu physician will approve eligibility.

inclusion criteria: * men and women between the ages 18-80 years * diagnosis of covid19 with severe ards (pao2/fio2 \<150mmhg) * admission to the icu and in need of mechanical ventilation * able to give informed consent according to local regulations. if the patient is unable to give written informed consent, the form will be read to them and their verbal consent will be documented. if the patient is sedated, an impartial icu physician will approve eligibility.

inclusion criteria: - men and women between the ages 18-80 years - diagnosis of covid19 with severe ards (pao2/fio2 <150mmhg) - admission to the icu and in need of mechanical ventilation - able to give informed consent according to local regulations. if the patient is unable to give written informed consent, the form will be read to them and their verbal consent will be documented. if the patient is sedated, an impartial icu physician will approve eligibility.

inclusion criteria: - men and women between the ages 18-80 years - diagnosis of covid19 with severe ards (pao2/fio2 <150mmhg) - admission to the icu and in need of mechanical ventilation - able to give informed consent according to local regulations. if the patient is unable to give written informed consent, the form will be read to them and their verbal consent will be documented. if the patient is sedated, an impartial icu physician will approve eligibility.