inclusion criteria: * age greater than or equal to 18 * admitted to a study hospital * active covid-19 defined as symptoms + sars cov-2 identified from upper or lower airway samples and blood * negative pregnancy test taken before inclusion and use of an acceptable effective method of contraception until treatment discontinuation if the participant is a woman of childbearing potential * written informed consent after meeting with a study physician and ability and willingness to complete follow up

inclusion criteria: * age greater than or equal to 18 * admitted to a study hospital * active covid-19 defined as symptoms + sars cov-2 identified from upper or lower airway samples and blood * negative pregnancy test taken before inclusion and use of an acceptable effective method of contraception until treatment discontinuation if the participant is a woman of childbearing potential * written informed consent after meeting with a study physician and ability and willingness to complete follow up

inclusion criteria: - age greater than or equal to 18 - admitted to a study hospital - active covid-19 defined as symptoms + sars cov-2 identified from upper or lower airway samples and blood - negative pregnancy test taken before inclusion and use of an acceptable effective method of contraception until treatment discontinuation if the participant is a woman of childbearing potential - written informed consent after meeting with a study physician and ability and willingness to complete follow up

inclusion criteria: - age greater than or equal to 18 - admitted to a study hospital - active covid-19 defined as symptoms + sars cov-2 identified from upper or lower airway samples and blood - negative pregnancy test taken before inclusion and use of an acceptable effective method of contraception until treatment discontinuation if the participant is a woman of childbearing potential - written informed consent after meeting with a study physician and ability and willingness to complete follow up