inclusion criteria: * consenting adults (age ≥18) hospitalised with definite covid-19 * patients without known allergy or contra-indications to any of the of the therapies and without anticipated transfer within 72 hours to a non- study hospital. * patients admitted to a collaborating hospital exclusion criteria * available study drugs are contra-indicated (e.g., because of patient characteristics, chronic liver or heart disease, or some concurrent medication).

inclusion criteria: * consenting adults (age ≥18) hospitalised with definite covid-19 * patients without known allergy or contra-indications to any of the of the therapies and without anticipated transfer within 72 hours to a non- study hospital. * patients admitted to a collaborating hospital exclusion criteria * available study drugs are contra-indicated (e.g., because of patient characteristics, chronic liver or heart disease, or some concurrent medication).

inclusion criteria: - consenting adults (age ≥18) hospitalised with definite covid-19 - patients without known allergy or contra-indications to any of the of the therapies and without anticipated transfer within 72 hours to a non- study hospital. - patients admitted to a collaborating hospital exclusion criteria - available study drugs are contra-indicated (e.g., because of patient characteristics, chronic liver or heart disease, or some concurrent medication).

inclusion criteria: - consenting adults (age ≥18) hospitalised with definite covid-19 - patients without known allergy or contra-indications to any of the of the therapies and without anticipated transfer within 72 hours to a non- study hospital. - patients admitted to a collaborating hospital exclusion criteria - available study drugs are contra-indicated (e.g., because of patient characteristics, chronic liver or heart disease, or some concurrent medication).