i (first step): * patients \>80 years of age * patient included in any other interventional trial * indication for imminent or immediate transfer to icu * treatment with tcz (or other anti-il-6r treatment) within 4 weeks prior to baseline * uncontrolled bacterial superinfection according to investigator * history of severe allergic reaction to tcz * history of diverticulitis requiring antibiotic treatment or history of colon perforation * history of primary immunodeficiency (e.g. cvid) or progressing malignancy * history of chronic liver disease (\>child-pugh a, or according to investigator) ii (second step; contraindication for intervention): * alanine transaminase/aspartate transaminase (alt/ast) \>5 times of the upper limit of normal * hemoglobin \<80 g/l * leukocytes \<2.0 g/l * absolute neutrophil count \<1.0 g/l * platelets \<50 g/l

i (first step): * patients \>80 years of age * patient included in any other interventional trial * indication for imminent or immediate transfer to icu * treatment with tcz (or other anti-il-6r treatment) within 4 weeks prior to baseline * uncontrolled bacterial superinfection according to investigator * history of severe allergic reaction to tcz * history of diverticulitis requiring antibiotic treatment or history of colon perforation * history of primary immunodeficiency (e.g. cvid) or progressing malignancy * history of chronic liver disease (\>child-pugh a, or according to investigator) ii (second step; contraindication for intervention): * alanine transaminase/aspartate transaminase (alt/ast) \>5 times of the upper limit of normal * hemoglobin \<80 g/l * leukocytes \<2.0 g/l * absolute neutrophil count \<1.0 g/l * platelets \<50 g/l

i (first step): - patients >80 years of age - patient included in any other interventional trial - indication for imminent or immediate transfer to icu - treatment with tcz (or other anti-il-6r treatment) within 4 weeks prior to baseline - uncontrolled bacterial superinfection according to investigator - history of severe allergic reaction to tcz - history of diverticulitis requiring antibiotic treatment or history of colon perforation - history of primary immunodeficiency (e.g. cvid) or progressing malignancy - history of chronic liver disease (>child-pugh a, or according to investigator) ii (second step; contraindication for intervention): - alanine transaminase/aspartate transaminase (alt/ast) >5 times of the upper limit of normal - hemoglobin <80 g/l - leukocytes <2.0 g/l - absolute neutrophil count <1.0 g/l - platelets <50 g/l

i (first step): - patients >80 years of age - patient included in any other interventional trial - indication for imminent or immediate transfer to icu - treatment with tcz (or other anti-il-6r treatment) within 4 weeks prior to baseline - uncontrolled bacterial superinfection according to investigator - history of severe allergic reaction to tcz - history of diverticulitis requiring antibiotic treatment or history of colon perforation - history of primary immunodeficiency (e.g. cvid) or progressing malignancy - history of chronic liver disease (>child-pugh a, or according to investigator) ii (second step; contraindication for intervention): - alanine transaminase/aspartate transaminase (alt/ast) >5 times of the upper limit of normal - hemoglobin <80 g/l - leukocytes <2.0 g/l - absolute neutrophil count <1.0 g/l - platelets <50 g/l