* shortness of breath, hypoxia, or signs of serious lower airway disease. * c-reactive protein, lactate dehydrogenase (ldh), or interleukin-6 (il-6) \> 1.5 x uln. * d-dimer or ferritin \> 1.5 x uln. * imminently requiring, or currently on, mechanical ventilation or extracorporeal membrane oxygenation (ecmo). * systolic blood pressure \< 90 mm hg or diastolic blood pressure \< 60 mm hg. * evidence of acute respiratory distress syndrome (ards) or systemic inflammatory response syndrome (sirs)/shock. * known cardiovascular history, including unstable or deteriorating cardiac disease. * autoimmune disease. * history of pulmonary embolism (pe), deep vein thrombosis (dvt), or prior clinically significant venous or non-cerebrovascular accident/transient ischemic attack arterial thromboembolic event. * central nervous system disease or dysfunction. * requirement for \> 2 anti-hypertensive medications. * unwilling to refrain from alcohol consumption from day 1 of admission to the in-patient facility until discharge from the facility. * adrenal insufficiency. note: other protocol defined inclusion/exclusion criteria may apply.

* shortness of breath, hypoxia, or signs of serious lower airway disease. * c-reactive protein, lactate dehydrogenase (ldh), or interleukin-6 (il-6) \> 1.5 x uln. * d-dimer or ferritin \> 1.5 x uln. * imminently requiring, or currently on, mechanical ventilation or extracorporeal membrane oxygenation (ecmo). * systolic blood pressure \< 90 mm hg or diastolic blood pressure \< 60 mm hg. * evidence of acute respiratory distress syndrome (ards) or systemic inflammatory response syndrome (sirs)/shock. * known cardiovascular history, including unstable or deteriorating cardiac disease. * autoimmune disease. * history of pulmonary embolism (pe), deep vein thrombosis (dvt), or prior clinically significant venous or non-cerebrovascular accident/transient ischemic attack arterial thromboembolic event. * central nervous system disease or dysfunction. * requirement for \> 2 anti-hypertensive medications. * unwilling to refrain from alcohol consumption from day 1 of admission to the in-patient facility until discharge from the facility. * adrenal insufficiency. note: other protocol defined inclusion/exclusion criteria may apply.

- shortness of breath, hypoxia, or signs of serious lower airway disease. - c-reactive protein, lactate dehydrogenase (ldh), or interleukin-6 (il-6) > 1.5 x uln. - d-dimer or ferritin > 1.5 x uln. - imminently requiring, or currently on, mechanical ventilation or extracorporeal membrane oxygenation (ecmo). - systolic blood pressure < 90 mm hg or diastolic blood pressure < 60 mm hg. - evidence of acute respiratory distress syndrome (ards) or systemic inflammatory response syndrome (sirs)/shock. - known cardiovascular history, including unstable or deteriorating cardiac disease. - autoimmune disease. - history of pulmonary embolism (pe), deep vein thrombosis (dvt), or prior clinically significant venous or non-cerebrovascular accident/transient ischemic attack arterial thromboembolic event. - central nervous system disease or dysfunction. - requirement for > 2 anti-hypertensive medications. - unwilling to refrain from alcohol consumption from day 1 of admission to the in-patient facility until discharge from the facility. - adrenal insufficiency. note: other protocol defined inclusion/exclusion criteria may apply.

- shortness of breath, hypoxia, or signs of serious lower airway disease. - c-reactive protein, lactate dehydrogenase (ldh), or interleukin-6 (il-6) > 1.5 x uln. - d-dimer or ferritin > 1.5 x uln. - imminently requiring, or currently on, mechanical ventilation or extracorporeal membrane oxygenation (ecmo). - systolic blood pressure < 90 mm hg or diastolic blood pressure < 60 mm hg. - evidence of acute respiratory distress syndrome (ards) or systemic inflammatory response syndrome (sirs)/shock. - known cardiovascular history, including unstable or deteriorating cardiac disease. - autoimmune disease. - history of pulmonary embolism (pe), deep vein thrombosis (dvt), or prior clinically significant venous or non-cerebrovascular accident/transient ischemic attack arterial thromboembolic event. - central nervous system disease or dysfunction. - requirement for > 2 anti-hypertensive medications. - unwilling to refrain from alcohol consumption from day 1 of admission to the in-patient facility until discharge from the facility. - adrenal insufficiency. note: other protocol defined inclusion/exclusion criteria may apply.