inclusion criteria: * respiratory rate ≥ 30 * dyspnea and breathing difficulties findings * cases with oxygen saturation below 90% despite nasal oxygen support of 5 liters / minute and above * cases with partial oxygen pressure below 70 mmhg despite nasal oxygen support of 5 liters / minute and above * pao2 / fio2 \<300 lactate\> 4 mmol / l bilateral infiltrations or multi-lobar involvement on chest x-ray or tomography * hypotension (systolic blood pressure \<90 mmhg,\> 40 mmhg drop from usual skb, mean arterial pressure \<65 mmhg) * skin perfusion disorder organ dysfunction such as kidney function test, liver function test disorder, thrombocytopenia, confusion presence of immunosuppressive disease- presence of uncontrolled comorbidity with more than one feature * troponin height, arrhythmia * covid 19 test positivity

inclusion criteria: * respiratory rate ≥ 30 * dyspnea and breathing difficulties findings * cases with oxygen saturation below 90% despite nasal oxygen support of 5 liters / minute and above * cases with partial oxygen pressure below 70 mmhg despite nasal oxygen support of 5 liters / minute and above * pao2 / fio2 \<300 lactate\> 4 mmol / l bilateral infiltrations or multi-lobar involvement on chest x-ray or tomography * hypotension (systolic blood pressure \<90 mmhg,\> 40 mmhg drop from usual skb, mean arterial pressure \<65 mmhg) * skin perfusion disorder organ dysfunction such as kidney function test, liver function test disorder, thrombocytopenia, confusion presence of immunosuppressive disease- presence of uncontrolled comorbidity with more than one feature * troponin height, arrhythmia * covid 19 test positivity

inclusion criteria: - respiratory rate ≥ 30 - dyspnea and breathing difficulties findings - cases with oxygen saturation below 90% despite nasal oxygen support of 5 liters / minute and above - cases with partial oxygen pressure below 70 mmhg despite nasal oxygen support of 5 liters / minute and above - pao2 / fio2 <300 lactate> 4 mmol / l bilateral infiltrations or multi-lobar involvement on chest x-ray or tomography - hypotension (systolic blood pressure <90 mmhg,> 40 mmhg drop from usual skb, mean arterial pressure <65 mmhg) - skin perfusion disorder organ dysfunction such as kidney function test, liver function test disorder, thrombocytopenia, confusion presence of immunosuppressive disease- presence of uncontrolled comorbidity with more than one feature - troponin height, arrhythmia - covid 19 test positivity

inclusion criteria: - respiratory rate ≥ 30 - dyspnea and breathing difficulties findings - cases with oxygen saturation below 90% despite nasal oxygen support of 5 liters / minute and above - cases with partial oxygen pressure below 70 mmhg despite nasal oxygen support of 5 liters / minute and above - pao2 / fio2 <300 lactate> 4 mmol / l bilateral infiltrations or multi-lobar involvement on chest x-ray or tomography - hypotension (systolic blood pressure <90 mmhg,> 40 mmhg drop from usual skb, mean arterial pressure <65 mmhg) - skin perfusion disorder organ dysfunction such as kidney function test, liver function test disorder, thrombocytopenia, confusion presence of immunosuppressive disease- presence of uncontrolled comorbidity with more than one feature - troponin height, arrhythmia - covid 19 test positivity