inclusion criteria: 1. able to understand and sign the informed consent 2. sars-cov-2 positive on at least one upper respiratory swab or bronchoalveolar lavage 3. pao2 \<= 60 mmhg or spo2 \<= 90% or on oxygen therapy (any), cpap or nppv at randomization 4. age \>= 18 years old at randomization

inclusion criteria: 1. able to understand and sign the informed consent 2. sars-cov-2 positive on at least one upper respiratory swab or bronchoalveolar lavage 3. pao2 \<= 60 mmhg or spo2 \<= 90% or on oxygen therapy (any), cpap or nppv at randomization 4. age \>= 18 years old at randomization

inclusion criteria: able to understand and sign the informed consent sars-cov-2 positive on at least one upper respiratory swab or bronchoalveolar lavage pao2 <= 60 mmhg or spo2 <= 90% or on oxygen therapy (any), cpap or nppv at randomization age >= 18 years old at randomization

inclusion criteria: able to understand and sign the informed consent sars-cov-2 positive on at least one upper respiratory swab or bronchoalveolar lavage pao2 <= 60 mmhg or spo2 <= 90% or on oxygen therapy (any), cpap or nppv at randomization age >= 18 years old at randomization

inclusion criteria: 1. able to understand and sign the informed consent 2. sars-cov-2 positive on at least one upper respiratory swab or bronchoalveolar lavage 3. pao2 <= 60 mmhg or spo2 <= 90% or on oxygen therapy (any), cpap or nppv at randomization 4. age >= 18 years old at randomization

inclusion criteria: 1. able to understand and sign the informed consent 2. sars-cov-2 positive on at least one upper respiratory swab or bronchoalveolar lavage 3. pao2 <= 60 mmhg or spo2 <= 90% or on oxygen therapy (any), cpap or nppv at randomization 4. age >= 18 years old at randomization

inclusion criteria: 1. able to understand and sign the informed consent 2. sars-cov-2 positive on at least one upper respiratory swab or bronchoalveolar lavage 3. pao2 <= 60 mmhg or spo2 <= 90% or on hfnc, cpap or nppv at randomization 4. age >= 18 years old at randomization

inclusion criteria: 1. able to understand and sign the informed consent 2. sars-cov-2 positive on at least one upper respiratory swab or bronchoalveolar lavage 3. pao2 <= 60 mmhg or spo2 <= 90% or on hfnc, cpap or nppv at randomization 4. age >= 18 years old at randomization