inclusion criteria: 1. male or female patients aged 18 years and above; 2. hospitalised; 3. confirmed or suspected sars-cov-2 infection; 4. national early warning score (news2) greater than or equal to 3 in a single parameter or news2 \> 5 overall; 5. acute hypoxemic respiratory failure: pao2/fio2 ratio less than or equal to 300 or spo2/fio2 ratio \< 315 (kigali modification) 6. provision of written informed consent by the patient or by the patient's legal representative or professional consultee.

inclusion criteria: 1. male or female patients aged 18 years and above; 2. hospitalised; 3. confirmed or suspected sars-cov-2 infection; 4. national early warning score (news2) greater than or equal to 3 in a single parameter or news2 \> 5 overall; 5. acute hypoxemic respiratory failure: pao2/fio2 ratio less than or equal to 300 or spo2/fio2 ratio \< 315 (kigali modification) 6. provision of written informed consent by the patient or by the patient's legal representative or professional consultee.

inclusion criteria: male or female patients aged 18 years and above; hospitalised; confirmed or suspected sars-cov-2 infection; national early warning score (news2) greater than or equal to 3 in a single parameter or news2 > 5 overall; acute hypoxemic respiratory failure: pao2/fio2 ratio less than or equal to 300 or spo2/fio2 ratio < 315 (kigali modification) provision of written informed consent by the patient or by the patient's legal representative or professional consultee.

inclusion criteria: male or female patients aged 18 years and above; hospitalised; confirmed or suspected sars-cov-2 infection; national early warning score (news2) greater than or equal to 3 in a single parameter or news2 > 5 overall; acute hypoxemic respiratory failure: pao2/fio2 ratio less than or equal to 300 or spo2/fio2 ratio < 315 (kigali modification) provision of written informed consent by the patient or by the patient's legal representative or professional consultee.

inclusion criteria: 1. male or female patients aged 18 years and above; 2. hospitalised; 3. confirmed or suspected sars-cov-2 infection; 4. national early warning score (news2) greater than or equal to 3 in a single parameter or news2 > 5 overall; 5. acute hypoxemic respiratory failure: pao2/fio2 ratio less than or equal to 300 or spo2/fio2 ratio < 315 (kigali modification) 6. provision of written informed consent by the patient or by the patient's legal representative or professional consultee.

inclusion criteria: 1. male or female patients aged 18 years and above; 2. hospitalised; 3. confirmed or suspected sars-cov-2 infection; 4. national early warning score (news2) greater than or equal to 3 in a single parameter or news2 > 5 overall; 5. acute hypoxemic respiratory failure: pao2/fio2 ratio less than or equal to 300 or spo2/fio2 ratio < 315 (kigali modification) 6. provision of written informed consent by the patient or by the patient's legal representative or professional consultee.