1. any of the following contraindications to ibuprofen: * a known hypersensitivity to ibuprofen or any other constituent of the medicinal product; * patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema or urticaria) in response to aspirin or other non-steroidal anti-inflammatory drugs (nsaids); * patients with a history of, or existing gastrointestinal ulceration/perforation or bleeding, including that associated with nsaids; * patients with severe hepatic failure; * patients with acute renal failure; * patients with severe heart failure. 2. participation in any other investigational drug products less than 30 days prior to study enrolment; 3. glasgow coma score \< 12; 4. patients who cannot swallow oral capsules; 5. pregnant or lactating women; 6. any medical history that might, in the opinion of the attending clinician, put the patient at significant risk if he/she were to participate in the trial.

1. any of the following contraindications to ibuprofen: * a known hypersensitivity to ibuprofen or any other constituent of the medicinal product; * patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema or urticaria) in response to aspirin or other non-steroidal anti-inflammatory drugs (nsaids); * patients with a history of, or existing gastrointestinal ulceration/perforation or bleeding, including that associated with nsaids; * patients with severe hepatic failure; * patients with acute renal failure; * patients with severe heart failure. 2. participation in any other investigational drug products less than 30 days prior to study enrolment; 3. glasgow coma score \< 12; 4. patients who cannot swallow oral capsules; 5. pregnant or lactating women; 6. any medical history that might, in the opinion of the attending clinician, put the patient at significant risk if he/she were to participate in the trial.

any of the following contraindications to ibuprofen: a known hypersensitivity to ibuprofen or any other constituent of the medicinal product; patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema or urticaria) in response to aspirin or other non-steroidal anti-inflammatory drugs (nsaids); patients with a history of, or existing gastrointestinal ulceration/perforation or bleeding, including that associated with nsaids; patients with severe hepatic failure; patients with acute renal failure; patients with severe heart failure. participation in any other investigational drug products less than 30 days prior to study enrolment; glasgow coma score < 12; patients who cannot swallow oral capsules; pregnant or lactating women; any medical history that might, in the opinion of the attending clinician, put the patient at significant risk if he/she were to participate in the trial.

any of the following contraindications to ibuprofen: a known hypersensitivity to ibuprofen or any other constituent of the medicinal product; patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema or urticaria) in response to aspirin or other non-steroidal anti-inflammatory drugs (nsaids); patients with a history of, or existing gastrointestinal ulceration/perforation or bleeding, including that associated with nsaids; patients with severe hepatic failure; patients with acute renal failure; patients with severe heart failure. participation in any other investigational drug products less than 30 days prior to study enrolment; glasgow coma score < 12; patients who cannot swallow oral capsules; pregnant or lactating women; any medical history that might, in the opinion of the attending clinician, put the patient at significant risk if he/she were to participate in the trial.

1. any of the following contraindications to ibuprofen: - a known hypersensitivity to ibuprofen or any other constituent of the medicinal product; - patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema or urticaria) in response to aspirin or other non-steroidal anti-inflammatory drugs (nsaids); - patients with a history of, or existing gastrointestinal ulceration/perforation or bleeding, including that associated with nsaids; - patients with severe hepatic failure; - patients with acute renal failure; - patients with severe heart failure. 2. participation in any other investigational drug products less than 30 days prior to study enrolment; 3. glasgow coma score < 12; 4. patients who cannot swallow oral capsules; 5. pregnant or lactating women; 6. any medical history that might, in the opinion of the attending clinician, put the patient at significant risk if he/she were to participate in the trial.

1. any of the following contraindications to ibuprofen: - a known hypersensitivity to ibuprofen or any other constituent of the medicinal product; - patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema or urticaria) in response to aspirin or other non-steroidal anti-inflammatory drugs (nsaids); - patients with a history of, or existing gastrointestinal ulceration/perforation or bleeding, including that associated with nsaids; - patients with severe hepatic failure; - patients with acute renal failure; - patients with severe heart failure. 2. participation in any other investigational drug products less than 30 days prior to study enrolment; 3. glasgow coma score < 12; 4. patients who cannot swallow oral capsules; 5. pregnant or lactating women; 6. any medical history that might, in the opinion of the attending clinician, put the patient at significant risk if he/she were to participate in the trial.