* pregnant or lactating female of childbearing potential. * use of extracorporeal membrane oxygenation (ecmo). * uncontrolled hypertension (systolic blood pressure \[bp\] ≥160 mmhg and/or diastolic bp ≥100 mmhg), unstable angina, congestive heart failure of new york heart association classification iii or iv, serious cardiac arrhythmia requiring treatment at screening. * history of myocardial infarction within 1 month prior to screening.

* pregnant or lactating female of childbearing potential. * use of extracorporeal membrane oxygenation (ecmo). * uncontrolled hypertension (systolic blood pressure \[bp\] ≥160 mmhg and/or diastolic bp ≥100 mmhg), unstable angina, congestive heart failure of new york heart association classification iii or iv, serious cardiac arrhythmia requiring treatment at screening. * history of myocardial infarction within 1 month prior to screening.

- pregnant or lactating female of childbearing potential. - use of extracorporeal membrane oxygenation (ecmo). - uncontrolled hypertension (systolic blood pressure [bp] ≥160 mmhg and/or diastolic bp ≥100 mmhg), unstable angina, congestive heart failure of new york heart association classification iii or iv, serious cardiac arrhythmia requiring treatment at screening. - history of myocardial infarction within 1 month prior to screening.

- pregnant or lactating female of childbearing potential. - use of extracorporeal membrane oxygenation (ecmo). - uncontrolled hypertension (systolic blood pressure [bp] ≥160 mmhg and/or diastolic bp ≥100 mmhg), unstable angina, congestive heart failure of new york heart association classification iii or iv, serious cardiac arrhythmia requiring treatment at screening. - history of myocardial infarction within 1 month prior to screening.

- pregnant or lactating female of childbearing potential. - use of extracorporeal membrane oxygenation (ecmo) or ards. - uncontrolled hypertension (systolic blood pressure [bp] ≥160 mmhg and/or diastolic bp ≥100 mmhg), unstable angina, congestive heart failure of new york heart association classification iii or iv, serious cardiac arrhythmia requiring treatment. - history of myocardial infarction within 3 months prior to screening.

- pregnant or lactating female of childbearing potential. - use of extracorporeal membrane oxygenation (ecmo) or ards. - uncontrolled hypertension (systolic blood pressure [bp] ≥160 mmhg and/or diastolic bp ≥100 mmhg), unstable angina, congestive heart failure of new york heart association classification iii or iv, serious cardiac arrhythmia requiring treatment. - history of myocardial infarction within 3 months prior to screening.