inclusion criteria: 1. male or female or any race or ethnicity. 2. at least 18 years of age. 3. provide written informed consent. for subjects who are incapable of providing informed consent, written informed consent can be provided on behalf of the subject by a legally authorized representative (lar). 4. diagnosis of mild to severe ards per the berlin definition of ards. more specifically, the following 3 conditions must be present. 1. a need for positive pressure ventilation by an endotracheal or tracheal tube with a pao2/fio2 ratio \< 200 with at least 8 cm h2o positive end-expiratory airway pressure (peep). a patient may be included if the pao2/fio2 ratio \< 200 with \< 8 cm h2o peep if there is a contraindication to increased peep (evidence of barotrauma). 2. bilateral infiltrates consistent with pulmonary edema on frontal chest radiograph. 3. no clinical evidence of left atrial hypertension for bilateral pulmonary infiltrates. 5. confirmed diagnosis of infection with coronavirus or influenza virus. 6. willing to perform all assessments required for the study. 7. must agree to the collection of all blood samples per protocol. 8. must agree to have samples stored and used for secondary research.

inclusion criteria: 1. male or female or any race or ethnicity. 2. at least 18 years of age. 3. provide written informed consent. for subjects who are incapable of providing informed consent, written informed consent can be provided on behalf of the subject by a legally authorized representative (lar). 4. diagnosis of mild to severe ards per the berlin definition of ards. more specifically, the following 3 conditions must be present. 1. a need for positive pressure ventilation by an endotracheal or tracheal tube with a pao2/fio2 ratio \< 200 with at least 8 cm h2o positive end-expiratory airway pressure (peep). a patient may be included if the pao2/fio2 ratio \< 200 with \< 8 cm h2o peep if there is a contraindication to increased peep (evidence of barotrauma). 2. bilateral infiltrates consistent with pulmonary edema on frontal chest radiograph. 3. no clinical evidence of left atrial hypertension for bilateral pulmonary infiltrates. 5. confirmed diagnosis of infection with coronavirus or influenza virus. 6. willing to perform all assessments required for the study. 7. must agree to the collection of all blood samples per protocol. 8. must agree to have samples stored and used for secondary research.

inclusion criteria: male or female or any race or ethnicity. at least 18 years of age. provide written informed consent. for subjects who are incapable of providing informed consent, written informed consent can be provided on behalf of the subject by a legally authorized representative (lar). diagnosis of mild to severe ards per the berlin definition of ards. more specifically, the following 3 conditions must be present. a need for positive pressure ventilation by an endotracheal or tracheal tube with a pao2/fio2 ratio < 200 with at least 8 cm h2o positive end-expiratory airway pressure (peep). a patient may be included if the pao2/fio2 ratio < 200 with < 8 cm h2o peep if there is a contraindication to increased peep (evidence of barotrauma). bilateral infiltrates consistent with pulmonary edema on frontal chest radiograph. no clinical evidence of left atrial hypertension for bilateral pulmonary infiltrates. confirmed diagnosis of infection with coronavirus or influenza virus. willing to perform all assessments required for the study. must agree to the collection of all blood samples per protocol. must agree to have samples stored and used for secondary research.

inclusion criteria: male or female or any race or ethnicity. at least 18 years of age. provide written informed consent. for subjects who are incapable of providing informed consent, written informed consent can be provided on behalf of the subject by a legally authorized representative (lar). diagnosis of mild to severe ards per the berlin definition of ards. more specifically, the following 3 conditions must be present. a need for positive pressure ventilation by an endotracheal or tracheal tube with a pao2/fio2 ratio < 200 with at least 8 cm h2o positive end-expiratory airway pressure (peep). a patient may be included if the pao2/fio2 ratio < 200 with < 8 cm h2o peep if there is a contraindication to increased peep (evidence of barotrauma). bilateral infiltrates consistent with pulmonary edema on frontal chest radiograph. no clinical evidence of left atrial hypertension for bilateral pulmonary infiltrates. confirmed diagnosis of infection with coronavirus or influenza virus. willing to perform all assessments required for the study. must agree to the collection of all blood samples per protocol. must agree to have samples stored and used for secondary research.

inclusion criteria: 1. male or female or any race or ethnicity. 2. at least 18 years of age. 3. provide written informed consent. for subjects who are incapable of providing informed consent, written informed consent can be provided on behalf of the subject by a legally authorized representative (lar). 4. diagnosis of mild to severe ards per the berlin definition of ards. more specifically, the following 3 conditions must be present. 1. a need for positive pressure ventilation by an endotracheal or tracheal tube with a pao2/fio2 ratio < 200 with at least 8 cm h2o positive end-expiratory airway pressure (peep). a patient may be included if the pao2/fio2 ratio < 200 with < 8 cm h2o peep if there is a contraindication to increased peep (evidence of barotrauma). 2. bilateral infiltrates consistent with pulmonary edema on frontal chest radiograph. 3. no clinical evidence of left atrial hypertension for bilateral pulmonary infiltrates. 5. confirmed diagnosis of infection with coronavirus or influenza virus. 6. willing to perform all assessments required for the study. 7. must agree to the collection of all blood samples per protocol. 8. must agree to have samples stored and used for secondary research.

inclusion criteria: 1. male or female or any race or ethnicity. 2. at least 18 years of age. 3. provide written informed consent. for subjects who are incapable of providing informed consent, written informed consent can be provided on behalf of the subject by a legally authorized representative (lar). 4. diagnosis of mild to severe ards per the berlin definition of ards. more specifically, the following 3 conditions must be present. 1. a need for positive pressure ventilation by an endotracheal or tracheal tube with a pao2/fio2 ratio < 200 with at least 8 cm h2o positive end-expiratory airway pressure (peep). a patient may be included if the pao2/fio2 ratio < 200 with < 8 cm h2o peep if there is a contraindication to increased peep (evidence of barotrauma). 2. bilateral infiltrates consistent with pulmonary edema on frontal chest radiograph. 3. no clinical evidence of left atrial hypertension for bilateral pulmonary infiltrates. 5. confirmed diagnosis of infection with coronavirus or influenza virus. 6. willing to perform all assessments required for the study. 7. must agree to the collection of all blood samples per protocol. 8. must agree to have samples stored and used for secondary research.