age \< 18 pregnant allergic to experimental drugs and patients have the following conditions: * hypercholesterolemia * hypertriglyceridemia * liver disease * renal disease * sjögren syndrome * pregnancy * lactation * depressive disorder * body mass index less than 18 points or higher than 25 points * contraindications for hormonal contraception or intrauterine device. * autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation * patients receiving anti-hcv treatment * permanent blindness in one eye * history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery * known malignant disease, psa \> 3 ug/l, nycturia \> 3 times * the competent physician considered it inappropriate to participate in the study

age \< 18 pregnant allergic to experimental drugs and patients have the following conditions: * hypercholesterolemia * hypertriglyceridemia * liver disease * renal disease * sjögren syndrome * pregnancy * lactation * depressive disorder * body mass index less than 18 points or higher than 25 points * contraindications for hormonal contraception or intrauterine device. * autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation * patients receiving anti-hcv treatment * permanent blindness in one eye * history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery * known malignant disease, psa \> 3 ug/l, nycturia \> 3 times * the competent physician considered it inappropriate to participate in the study

age < 18 pregnant allergic to experimental drugs and patients have the following conditions: - hypercholesterolemia - hypertriglyceridemia - liver disease - renal disease - sjögren syndrome - pregnancy - lactation - depressive disorder - body mass index less than 18 points or higher than 25 points - contraindications for hormonal contraception or intrauterine device. - autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation - patients receiving anti-hcv treatment - permanent blindness in one eye - history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery - known malignant disease, psa > 3 ug/l, nycturia > 3 times - the competent physician considered it inappropriate to participate in the study

age < 18 pregnant allergic to experimental drugs and patients have the following conditions: - hypercholesterolemia - hypertriglyceridemia - liver disease - renal disease - sjögren syndrome - pregnancy - lactation - depressive disorder - body mass index less than 18 points or higher than 25 points - contraindications for hormonal contraception or intrauterine device. - autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation - patients receiving anti-hcv treatment - permanent blindness in one eye - history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery - known malignant disease, psa > 3 ug/l, nycturia > 3 times - the competent physician considered it inappropriate to participate in the study