inclusion criteria: * age 18-70 * proven covid-19/high clinical suspicion of covid-19 * hypoxia/respiratory compromise defined as requiring respiratory support of \>2l/min of oxygen by nasal cannulae to maintain spo2\<96%. * raised inflammatory parameters: at least 2 of the following: 1. raised ldh (\> 2 x uln) 2. raised d dimers (\> 2x uln) 3. raised crp (\>2x uln) * females of childbearing potential have a negative pregnancy test within 7 days prior to being randomised. participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal

inclusion criteria: * age 18-70 * proven covid-19/high clinical suspicion of covid-19 * hypoxia/respiratory compromise defined as requiring respiratory support of \>2l/min of oxygen by nasal cannulae to maintain spo2\<96%. * raised inflammatory parameters: at least 2 of the following: 1. raised ldh (\> 2 x uln) 2. raised d dimers (\> 2x uln) 3. raised crp (\>2x uln) * females of childbearing potential have a negative pregnancy test within 7 days prior to being randomised. participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal

inclusion criteria: age 18-70 proven covid-19/high clinical suspicion of covid-19 hypoxia/respiratory compromise defined as requiring respiratory support of >2l/min of oxygen by nasal cannulae to maintain spo2<96%. raised inflammatory parameters: at least 2 of the following: raised ldh (> 2 x uln) raised d dimers (> 2x uln) raised crp (>2x uln) females of childbearing potential have a negative pregnancy test within 7 days prior to being randomised. participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal

inclusion criteria: age 18-70 proven covid-19/high clinical suspicion of covid-19 hypoxia/respiratory compromise defined as requiring respiratory support of >2l/min of oxygen by nasal cannulae to maintain spo2<96%. raised inflammatory parameters: at least 2 of the following: raised ldh (> 2 x uln) raised d dimers (> 2x uln) raised crp (>2x uln) females of childbearing potential have a negative pregnancy test within 7 days prior to being randomised. participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal

inclusion criteria: - age 18-70 - proven covid-19/high clinical suspicion of covid-19 - hypoxia/respiratory compromise defined as requiring respiratory support of >2l/min of oxygen by nasal cannulae to maintain spo2<96%. - raised inflammatory parameters: at least 2 of the following: 1. raised ldh (> 2 x uln) 2. raised d dimers (> 2x uln) 3. raised crp (>2x uln) - females of childbearing potential have a negative pregnancy test within 7 days prior to being randomised. participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal

inclusion criteria: - age 18-70 - proven covid-19/high clinical suspicion of covid-19 - hypoxia/respiratory compromise defined as requiring respiratory support of >2l/min of oxygen by nasal cannulae to maintain spo2<96%. - raised inflammatory parameters: at least 2 of the following: 1. raised ldh (> 2 x uln) 2. raised d dimers (> 2x uln) 3. raised crp (>2x uln) - females of childbearing potential have a negative pregnancy test within 7 days prior to being randomised. participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal