* significant co-morbid illness with treatment escalation limited to cpap * active bleeding * pf ratio \< 100 on mechanical ventilation or noradrenaline requirement \> 0.5mcg/kg/min to maintain map \> 65mmhg (suggests futility) * known allergies to octaplas or excipients * females who are pregnant

* significant co-morbid illness with treatment escalation limited to cpap * active bleeding * pf ratio \< 100 on mechanical ventilation or noradrenaline requirement \> 0.5mcg/kg/min to maintain map \> 65mmhg (suggests futility) * known allergies to octaplas or excipients * females who are pregnant

- significant co-morbid illness with treatment escalation limited to cpap - active bleeding - pf ratio < 100 on mechanical ventilation or noradrenaline requirement > 0.5mcg/kg/min to maintain map > 65mmhg (suggests futility) - known allergies to octaplas or excipients - females who are pregnant

- significant co-morbid illness with treatment escalation limited to cpap - active bleeding - pf ratio < 100 on mechanical ventilation or noradrenaline requirement > 0.5mcg/kg/min to maintain map > 65mmhg (suggests futility) - known allergies to octaplas or excipients - females who are pregnant