* patient requires endotracheal intubation and mechanical ventilation, oxygen delivered by high-flow nasal cannula (heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates \>20 l/min with fraction of delivered oxygen ≥ 0.5), noninvasive positive pressure ventilation, extracorporeal membrane oxygenation (ecmo), or clinical diagnosis of respiratory failure. * patient with shock defined by systolic blood pressure \< 90 mm hg, or diastolic blood pressure \< 60 mm hg or requiring vasopressor. * patient with multi-organ dysfunction or failure defined by an increase in the sequential organ failure assessment score of 2 points or more. * patient is unlikely to survive beyond 2 days at the discretion of investigator. * patient has used chronic systemic corticosteroids within 2 weeks prior to screening. * patient with positive results for human immunodeficiency virus (hiv) or hepatitis b or c test. * patient has known active tuberculosis (tb), history of uncontrolled tb, suspected or known systemic bacterial or fungal infections within 4 weeks prior to screening. * patient has any other condition, which makes the patient unsuitable for study participation

* patient requires endotracheal intubation and mechanical ventilation, oxygen delivered by high-flow nasal cannula (heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates \>20 l/min with fraction of delivered oxygen ≥ 0.5), noninvasive positive pressure ventilation, extracorporeal membrane oxygenation (ecmo), or clinical diagnosis of respiratory failure. * patient with shock defined by systolic blood pressure \< 90 mm hg, or diastolic blood pressure \< 60 mm hg or requiring vasopressor. * patient with multi-organ dysfunction or failure defined by an increase in the sequential organ failure assessment score of 2 points or more. * patient is unlikely to survive beyond 2 days at the discretion of investigator. * patient has used chronic systemic corticosteroids within 2 weeks prior to screening. * patient with positive results for human immunodeficiency virus (hiv) or hepatitis b or c test. * patient has known active tuberculosis (tb), history of uncontrolled tb, suspected or known systemic bacterial or fungal infections within 4 weeks prior to screening. * patient has any other condition, which makes the patient unsuitable for study participation

- patient requires endotracheal intubation and mechanical ventilation, oxygen delivered by high-flow nasal cannula (heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates >20 l/min with fraction of delivered oxygen ≥ 0.5), noninvasive positive pressure ventilation, extracorporeal membrane oxygenation (ecmo), or clinical diagnosis of respiratory failure. - patient with shock defined by systolic blood pressure < 90 mm hg, or diastolic blood pressure < 60 mm hg or requiring vasopressor. - patient with multi-organ dysfunction or failure defined by an increase in the sequential organ failure assessment score of 2 points or more. - patient is unlikely to survive beyond 2 days at the discretion of investigator. - patient has used chronic systemic corticosteroids within 2 weeks prior to screening. - patient with positive results for human immunodeficiency virus (hiv) or hepatitis b or c test. - patient has known active tuberculosis (tb), history of uncontrolled tb, suspected or known systemic bacterial or fungal infections within 4 weeks prior to screening. - patient has any other condition, which makes the patient unsuitable for study participation

- patient requires endotracheal intubation and mechanical ventilation, oxygen delivered by high-flow nasal cannula (heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates >20 l/min with fraction of delivered oxygen ≥ 0.5), noninvasive positive pressure ventilation, extracorporeal membrane oxygenation (ecmo), or clinical diagnosis of respiratory failure. - patient with shock defined by systolic blood pressure < 90 mm hg, or diastolic blood pressure < 60 mm hg or requiring vasopressor. - patient with multi-organ dysfunction or failure defined by an increase in the sequential organ failure assessment score of 2 points or more. - patient is unlikely to survive beyond 2 days at the discretion of investigator. - patient has used chronic systemic corticosteroids within 2 weeks prior to screening. - patient with positive results for human immunodeficiency virus (hiv) or hepatitis b or c test. - patient has known active tuberculosis (tb), history of uncontrolled tb, suspected or known systemic bacterial or fungal infections within 4 weeks prior to screening. - patient has any other condition, which makes the patient unsuitable for study participation