inclusion criteria: 1. age \> 18 years 2. positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a pcr or antigen test result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. 3. moderate to severe hypoxemia defined by a baseline supplemental oxygen requirement of 6 liters or higher (including high flow oxygenation devices) as measured within the 24 hours before enrollment

inclusion criteria: 1. age \> 18 years 2. positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a pcr or antigen test result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. 3. moderate to severe hypoxemia defined by a baseline supplemental oxygen requirement of 6 liters or higher (including high flow oxygenation devices) as measured within the 24 hours before enrollment

inclusion criteria: age > 18 years positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a pcr or antigen test result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. moderate to severe hypoxemia defined by a baseline supplemental oxygen requirement of 6 liters or higher (including high flow oxygenation devices) as measured within the 24 hours before enrollment

inclusion criteria: age > 18 years positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a pcr or antigen test result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. moderate to severe hypoxemia defined by a baseline supplemental oxygen requirement of 6 liters or higher (including high flow oxygenation devices) as measured within the 24 hours before enrollment

inclusion criteria: 1. age > 18 years 2. positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a pcr or antigen test result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. 3. moderate to severe hypoxemia defined by a baseline supplemental oxygen requirement of 6 liters or higher (including high flow oxygenation devices) as measured within the 24 hours before enrollment

inclusion criteria: 1. age > 18 years 2. positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a pcr or antigen test result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. 3. moderate to severe hypoxemia defined by a baseline supplemental oxygen requirement of 6 liters or higher (including high flow oxygenation devices) as measured within the 24 hours before enrollment

inclusion criteria: 1. age > 18 years 2. positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a pcr test result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. 3. respiratory compromise defined by a baseline supplemental oxygen requirement of 6 liters or higher as measured within the 24 hours before enrollment

inclusion criteria: 1. age > 18 years 2. positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a pcr test result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. 3. respiratory compromise defined by a baseline supplemental oxygen requirement of 6 liters or higher as measured within the 24 hours before enrollment

inclusion criteria: 1. male or female, age > 18 years 2. positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. 3. respiratory compromise defined by a baseline supplemental oxygen requirement of 6 liters or higher as measured within the 24 hours before treatment

inclusion criteria: 1. male or female, age > 18 years 2. positive covid 19 test or clear clinical diagnosis of covid-19. positive covid-19 test will be confirmed based on a result or patient reported history. clear clinical diagnosis of covid-19 will be a combination of respiratory symptoms and clinical findings based on laboratory values and radiographs. 3. respiratory compromise defined by a baseline supplemental oxygen requirement of 6 liters or higher as measured within the 24 hours before treatment