inclusion criteria: * subjects who meet all of the following criteria may be included in the study: 1. men and women aged between 18 to 30 years of age, inclusive, on the day of signing the informed consent form (icf) 2. in good health with no history, or current evidence, of clinically significant medical conditions with particular reference to, but not restricted to, hypertension, diabetes, thromboembolic disorders, coronary heart disease, chronic obstructive lung disease, and no clinically significant test abnormalities that will interfere with subject safety, as defined by medical history, physical examination, vital signs (including oxygen saturation), ecg, spirometry, and safety laboratory tests as determined by the investigator 3. total body weight of greater or equal to 50 kg and body mass index (bmi) greater or equal to 18.0 kg/m2 and less than or equal to 28.0 kg/m2 (the upper limit of the bmi may be increased to less than or equal to 30 kg/m2 at the investigator's discretion in case of a muscular healthy subject for whom bmi may be biased upwards) 4. negative drugs of abuse, cotinine, and alcohol screen (unless explained by prescribed medication) 5. negative pregnancy test for women who have not been surgically sterilised 6. negative covid clear test

inclusion criteria: * subjects who meet all of the following criteria may be included in the study: 1. men and women aged between 18 to 30 years of age, inclusive, on the day of signing the informed consent form (icf) 2. in good health with no history, or current evidence, of clinically significant medical conditions with particular reference to, but not restricted to, hypertension, diabetes, thromboembolic disorders, coronary heart disease, chronic obstructive lung disease, and no clinically significant test abnormalities that will interfere with subject safety, as defined by medical history, physical examination, vital signs (including oxygen saturation), ecg, spirometry, and safety laboratory tests as determined by the investigator 3. total body weight of greater or equal to 50 kg and body mass index (bmi) greater or equal to 18.0 kg/m2 and less than or equal to 28.0 kg/m2 (the upper limit of the bmi may be increased to less than or equal to 30 kg/m2 at the investigator's discretion in case of a muscular healthy subject for whom bmi may be biased upwards) 4. negative drugs of abuse, cotinine, and alcohol screen (unless explained by prescribed medication) 5. negative pregnancy test for women who have not been surgically sterilised 6. negative covid clear test

inclusion criteria: subjects who meet all of the following criteria may be included in the study: men and women aged between 18 to 30 years of age, inclusive, on the day of signing the informed consent form (icf) in good health with no history, or current evidence, of clinically significant medical conditions with particular reference to, but not restricted to, hypertension, diabetes, thromboembolic disorders, coronary heart disease, chronic obstructive lung disease, and no clinically significant test abnormalities that will interfere with subject safety, as defined by medical history, physical examination, vital signs (including oxygen saturation), ecg, spirometry, and safety laboratory tests as determined by the investigator total body weight of greater or equal to 50 kg and body mass index (bmi) greater or equal to 18.0 kg/m2 and less than or equal to 28.0 kg/m2 (the upper limit of the bmi may be increased to less than or equal to 30 kg/m2 at the investigator's discretion in case of a muscular healthy subject for whom bmi may be biased upwards) negative drugs of abuse, cotinine, and alcohol screen (unless explained by prescribed medication) negative pregnancy test for women who have not been surgically sterilised negative covid clear test

inclusion criteria: subjects who meet all of the following criteria may be included in the study: men and women aged between 18 to 30 years of age, inclusive, on the day of signing the informed consent form (icf) in good health with no history, or current evidence, of clinically significant medical conditions with particular reference to, but not restricted to, hypertension, diabetes, thromboembolic disorders, coronary heart disease, chronic obstructive lung disease, and no clinically significant test abnormalities that will interfere with subject safety, as defined by medical history, physical examination, vital signs (including oxygen saturation), ecg, spirometry, and safety laboratory tests as determined by the investigator total body weight of greater or equal to 50 kg and body mass index (bmi) greater or equal to 18.0 kg/m2 and less than or equal to 28.0 kg/m2 (the upper limit of the bmi may be increased to less than or equal to 30 kg/m2 at the investigator's discretion in case of a muscular healthy subject for whom bmi may be biased upwards) negative drugs of abuse, cotinine, and alcohol screen (unless explained by prescribed medication) negative pregnancy test for women who have not been surgically sterilised negative covid clear test

inclusion criteria: - subjects who meet all of the following criteria may be included in the study: 1. men and women aged between 18 to 30 years of age, inclusive, on the day of signing the informed consent form (icf) 2. in good health with no history, or current evidence, of clinically significant medical conditions with particular reference to, but not restricted to, hypertension, diabetes, thromboembolic disorders, coronary heart disease, chronic obstructive lung disease, and no clinically significant test abnormalities that will interfere with subject safety, as defined by medical history, physical examination, vital signs (including oxygen saturation), ecg, spirometry, and safety laboratory tests as determined by the investigator 3. total body weight of greater or equal to 50 kg and body mass index (bmi) greater or equal to 18.0 kg/m2 and less than or equal to 28.0 kg/m2 (the upper limit of the bmi may be increased to less than or equal to 30 kg/m2 at the investigator's discretion in case of a muscular healthy subject for whom bmi may be biased upwards) 4. negative drugs of abuse, cotinine, and alcohol screen (unless explained by prescribed medication) 5. negative pregnancy test for women who have not been surgically sterilised 6. negative covid clear test

inclusion criteria: - subjects who meet all of the following criteria may be included in the study: 1. men and women aged between 18 to 30 years of age, inclusive, on the day of signing the informed consent form (icf) 2. in good health with no history, or current evidence, of clinically significant medical conditions with particular reference to, but not restricted to, hypertension, diabetes, thromboembolic disorders, coronary heart disease, chronic obstructive lung disease, and no clinically significant test abnormalities that will interfere with subject safety, as defined by medical history, physical examination, vital signs (including oxygen saturation), ecg, spirometry, and safety laboratory tests as determined by the investigator 3. total body weight of greater or equal to 50 kg and body mass index (bmi) greater or equal to 18.0 kg/m2 and less than or equal to 28.0 kg/m2 (the upper limit of the bmi may be increased to less than or equal to 30 kg/m2 at the investigator's discretion in case of a muscular healthy subject for whom bmi may be biased upwards) 4. negative drugs of abuse, cotinine, and alcohol screen (unless explained by prescribed medication) 5. negative pregnancy test for women who have not been surgically sterilised 6. negative covid clear test