inclusion criteria: * proven sars-cov2 infection * severe covid-19 (indicated by respiratory failure requiring invasive mechanical ventilation) * evidence of coagulopathy (indicated by d-dimer \> 10 mg/l) * evidence of systemic inflammation (crp \> 100 mg/l , ferritin \> 500 ng/ml)

inclusion criteria: * proven sars-cov2 infection * severe covid-19 (indicated by respiratory failure requiring invasive mechanical ventilation) * evidence of coagulopathy (indicated by d-dimer \> 10 mg/l) * evidence of systemic inflammation (crp \> 100 mg/l , ferritin \> 500 ng/ml)

inclusion criteria: - proven sars-cov2 infection - severe covid-19 (indicated by respiratory failure requiring invasive mechanical ventilation) - evidence of coagulopathy (indicated by d-dimer > 10 mg/l) - evidence of systemic inflammation (crp > 100 mg/l , ferritin > 500 ng/ml)

inclusion criteria: - proven sars-cov2 infection - severe covid-19 (indicated by respiratory failure requiring invasive mechanical ventilation) - evidence of coagulopathy (indicated by d-dimer > 10 mg/l) - evidence of systemic inflammation (crp > 100 mg/l , ferritin > 500 ng/ml)