inclusion criteria: * age range: healthy subjects aged 18 years old and above * by asking for medical history and physical examination, the investigator judged that the health condition is well * female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test), and do not plan to become pregnant within the first 3 months after enrolment . effective contraceptive measures have been taken within 2 weeks before inclusion and continued for at least three month s after last dose * during the whole follow up period of the study, be able and willing to complete the whole prescribed study plan. * with self ability to understand the research procedures, with informed consent, voluntarily sign an informed consent form, and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: * age range: healthy subjects aged 18 years old and above * by asking for medical history and physical examination, the investigator judged that the health condition is well * female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test), and do not plan to become pregnant within the first 3 months after enrolment . effective contraceptive measures have been taken within 2 weeks before inclusion and continued for at least three month s after last dose * during the whole follow up period of the study, be able and willing to complete the whole prescribed study plan. * with self ability to understand the research procedures, with informed consent, voluntarily sign an informed consent form, and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: - age range: healthy subjects aged 18 years old and above - by asking for medical history and physical examination, the investigator judged that the health condition is well - female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test), and do not plan to become pregnant within the first 3 months after enrolment . effective contraceptive measures have been taken within 2 weeks before inclusion and continued for at least three month s after last dose - during the whole follow up period of the study, be able and willing to complete the whole prescribed study plan. - with self ability to understand the research procedures, with informed consent, voluntarily sign an informed consent form, and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: - age range: healthy subjects aged 18 years old and above - by asking for medical history and physical examination, the investigator judged that the health condition is well - female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test), and do not plan to become pregnant within the first 3 months after enrolment . effective contraceptive measures have been taken within 2 weeks before inclusion and continued for at least three month s after last dose - during the whole follow up period of the study, be able and willing to complete the whole prescribed study plan. - with self ability to understand the research procedures, with informed consent, voluntarily sign an informed consent form, and be able to comply with the requirements of the clinical study protocol.