inclusion criteria: * age: adults 18 years and older * laboratory-confirmed covid-19+ by rt-pcr * moderate to severe covid-19 patients according to fda's covid-19 treatment guideline on management of persons with covid-19: moderate illness is defined as individuals who have evidence of lower respiratory disease by clinical assessment or imaging and a saturation of oxygen (spo2) \>93% on room air at sea level. severe illness is defined as individuals who have respiratory frequency \>30 breaths per minute, spo2 ≤ 93% on room air at sea level, ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (pao2/fio2) \<300, or lung infiltrates \>50% * written informed consent must be obtained before any study procedure is performed.

inclusion criteria: * age: adults 18 years and older * laboratory-confirmed covid-19+ by rt-pcr * moderate to severe covid-19 patients according to fda's covid-19 treatment guideline on management of persons with covid-19: moderate illness is defined as individuals who have evidence of lower respiratory disease by clinical assessment or imaging and a saturation of oxygen (spo2) \>93% on room air at sea level. severe illness is defined as individuals who have respiratory frequency \>30 breaths per minute, spo2 ≤ 93% on room air at sea level, ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (pao2/fio2) \<300, or lung infiltrates \>50% * written informed consent must be obtained before any study procedure is performed.

inclusion criteria: - age: adults 18 years and older - laboratory-confirmed covid-19+ by rt-pcr - moderate to severe covid-19 patients according to fda's covid-19 treatment guideline on management of persons with covid-19: moderate illness is defined as individuals who have evidence of lower respiratory disease by clinical assessment or imaging and a saturation of oxygen (spo2) >93% on room air at sea level. severe illness is defined as individuals who have respiratory frequency >30 breaths per minute, spo2 ≤ 93% on room air at sea level, ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (pao2/fio2) <300, or lung infiltrates >50% - written informed consent must be obtained before any study procedure is performed.

inclusion criteria: - age: adults 18 years and older - laboratory-confirmed covid-19+ by rt-pcr - moderate to severe covid-19 patients according to fda's covid-19 treatment guideline on management of persons with covid-19: moderate illness is defined as individuals who have evidence of lower respiratory disease by clinical assessment or imaging and a saturation of oxygen (spo2) >93% on room air at sea level. severe illness is defined as individuals who have respiratory frequency >30 breaths per minute, spo2 ≤ 93% on room air at sea level, ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (pao2/fio2) <300, or lung infiltrates >50% - written informed consent must be obtained before any study procedure is performed.